Assessment of silver nanoparticle (AgNP) suitability for use in polystyrene-based medical devices (CROSBI ID 702455)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Ilić, Krunoslav ; Krce, Lucija ; Rodriguez-Ramos, Jorge ; Rico, Felix ; Kalčec, Nikolina ; Aviani, Ivica ; Pavičić, Ivan ; Vinković Vrček, Ivana
engleski
Assessment of silver nanoparticle (AgNP) suitability for use in polystyrene-based medical devices
Introduction Silver nanoparticles are one of the most commercialized types of nanoparticles, with a wide range of applications owing to their antimicrobial activity. However, there is a lack of data on cumulative toxicity of silver nanoparticles used with polymeric materials, especially polymer nanoparticles. In this study, toxicity of PVP-coated silver nanoparticles (AgNP) combined with polystyrene nanoparticles (PSNP) was tested on Jurkat cells. Results Silver and polystyrene nanoparticles reduced cell viability through generation of reactive oxygen species (ROS), depletion of cellular GSH, and damage to cellular structures and mitochondria. Nanoparticle treatment also reduced cell stiffness, measured by Atomic Force Microscope (AFM), which is indicative of changes in cytoskeletal structure. Cellular treatment with combinations of non-toxic AgNP and PSNP concentrations resulted in significant induction of oxidative stress and reduction of cell viability. Conclusions AgNP share the mechanism of toxicity with PSNP and results for combined AgNP/PSNP treatments can be understood as compounded effect of overloading cellular mechanisms for managing oxidative stress. These results have important implications for use of these materials in medical contexts, particularly for long-term medical implants.
nanoparticles, silver, polystyrene, cytotoxicity, Jurkat
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
163
2021.
objavljeno
Podaci o matičnoj publikaciji
NanoTox 2021 Virtual Conference Book of Abstracts
Edinburgh:
Podaci o skupu
10th International Conference on Nanotoxicology (NanoTox 2021)
poster
20.04.2021-22.04.2021
Edinburgh, Ujedinjeno Kraljevstvo