Loss of thermotolerance in antibiotic-resistant Acinetobacter baumannii (CROSBI ID 293813)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Dekić Rozman, Svjetlana ; Butorac, Ana ; Bertoša, Rea ; Hrenović, Jasna ; Markeš, Marina
engleski
Loss of thermotolerance in antibiotic-resistant Acinetobacter baumannii
Bacterium Acinetobacter baumannii is a leading cause of nosocomial infections. The occurrence of antibiotic-resistant A. baumannii isolates outside hospitals suggests that monitoring of this pathogen in environmental samples is needed. Survival of pandrug-resistant A. baumannii was followed on selective plates with and without carbapenems in water and soil. After a few days of starvation, A. baumannii lost the ability to be cultivated at 44°C on plates supplemented with carbapenems. Once cultivated on plates without carbapenems and/or at 36°C, A. baumannii could grow again at 44°C in the presence of carbapenems. Comparative proteomic analysis revealed that impaired membrane integrity and reduced function of efflux pumps due to elevated temperature combined with antibiotic exposure were the main reasons for this phenomenon. Loss of thermotolerance in the presence of antibiotics points to the need for temperature adjustment in long-term monitoring of A. baumannii in environmental samples, to avoid the underestimation of viable bacteria.
Acinetobacter baumannii ; bacteria ; thermotolerance ; proteomics
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Podaci o izdanju
32 (7)
2021.
1581-1593
objavljeno
0960-3123
1369-1619
10.1080/09603123.2021.1898550