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Pregled bibliografske jedinice broj: 1123583

Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease


Raljević, Damir; Peršić, Viktor; Markova-Car, Elitza; Cindrić, Leon; Miškulin, Rajko; Žuvić, Marta; Kraljević Pavelić, Sandra
Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease // BMC Cardiovascular Disorders, 21 (2021), 1; 188, 9 doi:10.1186/s12872-021-01959-x (međunarodna recenzija, članak, znanstveni)


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Naslov
Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease

Autori
Raljević, Damir ; Peršić, Viktor ; Markova-Car, Elitza ; Cindrić, Leon ; Miškulin, Rajko ; Žuvić, Marta ; Kraljević Pavelić, Sandra

Izvornik
BMC Cardiovascular Disorders (1471-2261) 21 (2021), 1; 188, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BsmI ; Coronary artery disease ; Myocardial infarction ; RT-PCR ; Taq1 ; Vitamin D receptor gene polymorphisms

Sažetak
Background: Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Therefore, the objective of this study was to analyze three well-studied VDR gene polymorphisms- Fok1 (rs2228570), BsmI (rs1544410) and Taq1 (rs731236)-in a cohort of CAD patients after acute myocardial infarction. Methods: In the presented cross-sectional study, 155 participants with CAD after acute myocardial infarction and 104 participants in a control group without CAD were enrolled. The participants in both groups were Caucasians of European origin. The genotyping of VDR polymorphisms rs2228570, rs1544410 and rs731236 was assessed by RT-PCR. Results: The results show an association between the T/T genotype of the BsmI (rs1544410) and the G/G genotype of the Taq1 (rs731236) VDR polymorphism and CAD patients after acute myocardial infarction. There was no association between the Fok1 (rs2228570) VDR polymorphism and CAD patients after acute myocardial infarction. Conclusion: The presented results suggest a potential association of the BsmI (rs1544410) and Taq1 (rs731236) VDR polymorphisms with CAD patients after myocardial infarction.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
NadSve-Sveučilište u Rijeci-uniri-biomed-18-257 - Cirkadijalni geni u planocelularnog karcinoma larinksa (Markova-Car, Elitza Petkova; Markova-Car, Elitza Petkova, NadSve ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Sveučilište u Rijeci - Odjel za biotehnologiju,
Thalassoterapia Opatija,
Fakultet zdravstvenih studija u Rijeci

Poveznice na cjeloviti tekst rada:

doi bmccardiovascdisord.biomedcentral.com

Citiraj ovu publikaciju:

Raljević, Damir; Peršić, Viktor; Markova-Car, Elitza; Cindrić, Leon; Miškulin, Rajko; Žuvić, Marta; Kraljević Pavelić, Sandra
Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease // BMC Cardiovascular Disorders, 21 (2021), 1; 188, 9 doi:10.1186/s12872-021-01959-x (međunarodna recenzija, članak, znanstveni)
Raljević, D., Peršić, V., Markova-Car, E., Cindrić, L., Miškulin, R., Žuvić, M. & Kraljević Pavelić, S. (2021) Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease. BMC Cardiovascular Disorders, 21 (1), 188, 9 doi:10.1186/s12872-021-01959-x.
@article{article, author = {Raljevi\'{c}, Damir and Per\v{s}i\'{c}, Viktor and Markova-Car, Elitza and Cindri\'{c}, Leon and Mi\v{s}kulin, Rajko and \v{Z}uvi\'{c}, Marta and Kraljevi\'{c} Paveli\'{c}, Sandra}, year = {2021}, pages = {9}, DOI = {10.1186/s12872-021-01959-x}, chapter = {188}, keywords = {BsmI, Coronary artery disease, Myocardial infarction, RT-PCR, Taq1, Vitamin D receptor gene polymorphisms}, journal = {BMC Cardiovascular Disorders}, doi = {10.1186/s12872-021-01959-x}, volume = {21}, number = {1}, issn = {1471-2261}, title = {Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease}, keyword = {BsmI, Coronary artery disease, Myocardial infarction, RT-PCR, Taq1, Vitamin D receptor gene polymorphisms}, chapternumber = {188} }
@article{article, author = {Raljevi\'{c}, Damir and Per\v{s}i\'{c}, Viktor and Markova-Car, Elitza and Cindri\'{c}, Leon and Mi\v{s}kulin, Rajko and \v{Z}uvi\'{c}, Marta and Kraljevi\'{c} Paveli\'{c}, Sandra}, year = {2021}, pages = {9}, DOI = {10.1186/s12872-021-01959-x}, chapter = {188}, keywords = {BsmI, Coronary artery disease, Myocardial infarction, RT-PCR, Taq1, Vitamin D receptor gene polymorphisms}, journal = {BMC Cardiovascular Disorders}, doi = {10.1186/s12872-021-01959-x}, volume = {21}, number = {1}, issn = {1471-2261}, title = {Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease}, keyword = {BsmI, Coronary artery disease, Myocardial infarction, RT-PCR, Taq1, Vitamin D receptor gene polymorphisms}, chapternumber = {188} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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