engleski

Impact of mesoporous silica on the chemical degradation of Praziquantel upon grinding

Praziquantel and Syloid 244 FP (amorphous silicon dioxide) were ground in a vibrational mill in standard conditions (15’ or 30‘ at 25 Hz). Amorphous solid dispersions were obtained in a very short grinding time (15 min), as testified by DSC, PXRD and ESEM analyses. Samples ground at 15’ and 30’ evidenced the presence of the same degradation product, as evident from UPLC, MS and NMR analyses. This short paper put in light the tremendous lattice de-structuration ability of Syloid 244 FP upon grinding towards Praziquantel as well as its detrimental influence on promoting chemical degradation through ring opening and oxidation.

degradation products ; grinding ; mesoporous silica ; oxidation ; Praziquantel ; ring opening

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