Association of Pentraxin-3, Galectin-3 and Matrix Metalloproteinase-9/Timp-1 with Cardiovascular Risk in Renal Disease Patients (CROSBI ID 293575)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Miljković, Milica ; Stefanović, Aleksandra ; Bogavac-Stanojević, Nataša ; Simić-Ogrizović, Sanja ; Dumić, Jerka ; Černe, Darko ; Jelić- Ivanović, Zorana ; Kotur-Stevuljević, Jelena
engleski
Association of Pentraxin-3, Galectin-3 and Matrix Metalloproteinase-9/Timp-1 with Cardiovascular Risk in Renal Disease Patients
Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre- dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin- 3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p<0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre- dialysis patients and controls (p<0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p<0.01 and p<0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event.
ardiovascular diseases ; Galectin-3 ; Kidney diseases ; Matrix-metalloproteinase-9 ; Pentraxin-3 ; Tissue inhibitor of matrix metalloproteinase-1
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Podaci o izdanju
56 (4)
2017.
673-680
objavljeno
0353-9466
1333-9451
10.20471/acc.2017.56.04.14
Povezanost rada
nije evidentirano