engleski

Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents

Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti- inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti- inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFalpha and IL-8 release with IC50 values in µM range without cytotoxic activity.

thiazole ; small chemical fragments ; library design ; anti-inflammatory activity

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