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Pregled bibliografske jedinice broj: 1122302

Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents


Modrić, Marina; Božičević, Marin; Faraho, Ivan; Bosnar, Martina; Škorić, Irena
Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents // Journal of molecular structure, 1239 (2021), 130526, 12 doi:10.1016/j.molstruc.2021.130526 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1122302 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents

Autori
Modrić, Marina ; Božičević, Marin ; Faraho, Ivan ; Bosnar, Martina ; Škorić, Irena

Izvornik
Journal of molecular structure (0022-2860) 1239 (2021); 130526, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Thiazole ; Small chemical fragments ; Library design ; Anti-inflammatory activity

Sažetak
Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti- inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti- inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFalpha and IL-8 release with IC50 values in µM range without cytotoxic activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Fidelta d.o.o.

doi

Citiraj ovu publikaciju

Modrić, Marina; Božičević, Marin; Faraho, Ivan; Bosnar, Martina; Škorić, Irena
Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents // Journal of molecular structure, 1239 (2021), 130526, 12 doi:10.1016/j.molstruc.2021.130526 (međunarodna recenzija, članak, znanstveni)
Modrić, M., Božičević, M., Faraho, I., Bosnar, M. & Škorić, I. (2021) Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents. Journal of molecular structure, 1239, 130526, 12 doi:10.1016/j.molstruc.2021.130526.
@article{article, year = {2021}, pages = {12}, DOI = {10.1016/j.molstruc.2021.130526}, chapter = {130526}, keywords = {Thiazole, Small chemical fragments, Library design, Anti-inflammatory activity}, journal = {Journal of molecular structure}, doi = {10.1016/j.molstruc.2021.130526}, volume = {1239}, issn = {0022-2860}, title = {Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents}, keyword = {Thiazole, Small chemical fragments, Library design, Anti-inflammatory activity}, chapternumber = {130526} }
@article{article, year = {2021}, pages = {12}, DOI = {10.1016/j.molstruc.2021.130526}, chapter = {130526}, keywords = {Thiazole, Small chemical fragments, Library design, Anti-inflammatory activity}, journal = {Journal of molecular structure}, doi = {10.1016/j.molstruc.2021.130526}, volume = {1239}, issn = {0022-2860}, title = {Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti- inflammatory agents}, keyword = {Thiazole, Small chemical fragments, Library design, Anti-inflammatory activity}, chapternumber = {130526} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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