engleski

Erythrocytosis and thrombocytosis secondary to hyperandrogenism caused by ovarian Leydig cell tumor

Both erytroblasts and megakaryocytes contain androgen receptors, and testosterone regulates their expression. However, the exact mechanisms of testosterone's hematopoietic effects are poorly understood. We report a case of perimenopausal woman with severe hyperandrogenism caused by pure Leydig cell ovarian tumor accompanied by concomitant erythrocytosis and thrombocytosis. Substantial, immediate, and persistent decrease in both red blood cell count and platelet count after testosterone-secreting tumor removal in our patient suggests testosterone's synergistic effect on erythropoiesis and thrombopoiesis.

testosterone, hematopoesis, erytrocytosis, trombocytosis, Leydig cell tumor

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