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Pregled bibliografske jedinice broj: 1119148

Optineurin Dysfunction in Amyotrophic Lateral Sclerosis: Why So Puzzling?


Prtenjaca, Nikolina; Dominovic, Marin; Peradinovic, Josip; Šajn, Rozalija; Markovinovic, Andrea; Munitic, Ivana
Optineurin Dysfunction in Amyotrophic Lateral Sclerosis: Why So Puzzling? // Periodicum biologorum, 121-122 (2020), 1-2; 23-34 doi:10.18054/pb.v121-122i1-2.10627 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1119148 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Optineurin Dysfunction in Amyotrophic Lateral Sclerosis: Why So Puzzling?
(Optineurin Dysfunction in Amyotrophic Lateral Sclerosis: Why So Puzzling?)

Autori
Prtenjaca, Nikolina ; Dominovic, Marin ; Peradinovic, Josip ; Šajn, Rozalija ; Markovinovic, Andrea ; Munitic, Ivana

Izvornik
Periodicum biologorum (0031-5362) 121-122 (2020), 1-2; 23-34

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
optineurin ; ALS

Sažetak
Mutations in optineurin have been linked to amyotrophic lateral sclero- sis (ALS) a decade ago, but its exact role in the neurodegenerative process is still unclear. As a lysine 63 (K63)- and methionine (M1)-linked polyubiq- uitin-binding protein, optineurin has been reported to act as an adaptor in inflammatory signaling pathways mediated via nuclear factor kappa-light- chain-enhancer of activated B cells (NF-κB) and interferon regulatory fac- tor 3 (IRF3), as well as in membrane-associated trafficking events including autophagy, maintenance of the Golgi apparatus, and exocytosis. Other stud- ies have demonstrated its role in other processes such as regulation of mitosis, transcription, necroptosis and apoptosis. However, many of the reported effects in cell models have been proven difficult to reproduce in optineurin animal models, demonstrating the challenges of extrapolation between model systems. Knowing that multifunctional proteins present a “nightmare” for researchers, to help navigating through this field, we address the most common controversies, open questions, and artefacts related to optineurin and its role in pathogenesis of ALS and other neurodegenerative diseases.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
IP-2018-01-8563 - Kontrola neurodegeneracije moduliranjem sprege između upale i proteinopatije (ImmunoModifyCNS) (Munitić, Ivana, HRZZ - 2018-01) ( POIROT)

Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju

Poveznice na cjeloviti tekst rada:

doi hrcak.srce.hr

Citiraj ovu publikaciju:

Prtenjaca, Nikolina; Dominovic, Marin; Peradinovic, Josip; Šajn, Rozalija; Markovinovic, Andrea; Munitic, Ivana
Optineurin Dysfunction in Amyotrophic Lateral Sclerosis: Why So Puzzling? // Periodicum biologorum, 121-122 (2020), 1-2; 23-34 doi:10.18054/pb.v121-122i1-2.10627 (međunarodna recenzija, članak, znanstveni)
Prtenjaca, N., Dominovic, M., Peradinovic, J., Šajn, R., Markovinovic, A. & Munitic, I. (2020) Optineurin Dysfunction in Amyotrophic Lateral Sclerosis: Why So Puzzling?. Periodicum biologorum, 121-122 (1-2), 23-34 doi:10.18054/pb.v121-122i1-2.10627.
@article{article, year = {2020}, pages = {23-34}, DOI = {10.18054/pb.v121-122i1-2.10627}, keywords = {optineurin, ALS}, journal = {Periodicum biologorum}, doi = {10.18054/pb.v121-122i1-2.10627}, volume = {121-122}, number = {1-2}, issn = {0031-5362}, title = {Optineurin Dysfunction in Amyotrophic Lateral Sclerosis: Why So Puzzling?}, keyword = {optineurin, ALS} }
@article{article, year = {2020}, pages = {23-34}, DOI = {10.18054/pb.v121-122i1-2.10627}, keywords = {optineurin, ALS}, journal = {Periodicum biologorum}, doi = {10.18054/pb.v121-122i1-2.10627}, volume = {121-122}, number = {1-2}, issn = {0031-5362}, title = {Optineurin Dysfunction in Amyotrophic Lateral Sclerosis: Why So Puzzling?}, keyword = {optineurin, ALS} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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