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Pregled bibliografske jedinice broj: 1118868

Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review


Odžak, Renata; Šprung, Matilda
Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review // Periodicum biologorum, 121-122 (2020), 1-2; 15-21 (međunarodna recenzija, članak, znanstveni)


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Naslov
Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review

Autori
Odžak, Renata ; Šprung, Matilda

Izvornik
Periodicum biologorum (0031-5362) 121-122 (2020), 1-2; 15-21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hrčak, hrcak, znanstveni časopisi, hrvatski, scientific journals, croatian

Sažetak
Quaternary ammonium compounds (QACs) have a long- known application as antiseptics and disinfectants applied in various industries such as pharmaceutical, agricultural and food industry. Given the alarming number of QACs resistant bacteria, there is an urgent need to develop new QACs with broad-spectrum antimicrobial activities and low tendency to trigger bacterial resistance. One recently proposed approach to develop new QACs is based on quaternization of natural products, which proved to be successful. Quinuclidine is an interesting natural precursor find to be a part of the structure of biologically active cinchona alkaloids. In addition to the well- established medicinal and pharmaceutical potential of 3-substituted quinuclidines, QACs based on 3- substituted quinuclidines, have only recently been shown to exhibit a significant antimicrobial activity. Most importantly, these compounds exhibit low toxicity toward normal human cell lines, which opens up a new chapter in the QACs field ensuring further investigation of possible therapeutic application of 3-substituted quinuclidine based QACs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove:
Prirodoslovno-matematički fakultet, Split

Profili:

Avatar Url Matilda Šprung (autor)

Avatar Url Renata Odžak (autor)


Citiraj ovu publikaciju

Odžak, Renata; Šprung, Matilda
Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review // Periodicum biologorum, 121-122 (2020), 1-2; 15-21 (međunarodna recenzija, članak, znanstveni)
Odžak, R. & Šprung, M. (2020) Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review. Periodicum biologorum, 121-122 (1-2), 15-21.
@article{article, year = {2020}, pages = {15-21}, keywords = {hr\v{c}ak, hrcak, znanstveni \v{c}asopisi, hrvatski, scientific journals, croatian}, journal = {Periodicum biologorum}, volume = {121-122}, number = {1-2}, issn = {0031-5362}, title = {Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review}, keyword = {hr\v{c}ak, hrcak, znanstveni \v{c}asopisi, hrvatski, scientific journals, croatian} }
@article{article, year = {2020}, pages = {15-21}, keywords = {hr\v{c}ak, hrcak, znanstveni \v{c}asopisi, hrvatski, scientific journals, croatian}, journal = {Periodicum biologorum}, volume = {121-122}, number = {1-2}, issn = {0031-5362}, title = {Biological activity of monoquaternary ammonium compounds based on 3-substituted quinuclidine: A short review}, keyword = {hr\v{c}ak, hrcak, znanstveni \v{c}asopisi, hrvatski, scientific journals, croatian} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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