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Pregled bibliografske jedinice broj: 1116990

Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents


Matošević, Ana; Bosak, Anita
Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents // Arhiv za higijenu rada i toksikologiju, 71 (2020), 4; 285-299 (međunarodna recenzija, pregledni rad, ostalo)


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Naslov
Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents

Autori
Matošević, Ana ; Bosak, Anita

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 71 (2020), 4; 285-299

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, ostalo

Ključne riječi
anticonvulsants ; antiepileptics ; cholinesterase inhibitors ; neurodegenerative diseases ; prodrugs ; protease inhibitors

Sažetak
Due to their very good chemical and proteolytic stability, ability to penetrate cell membranes, and resemblance to a peptide bond, carbamate derivatives have received much attention in recent years and got an important role in modern drug discovery and medicinal chemistry. Today, carbamates make structural and/or functional part of many drugs and prodrugs approved and marketed for the treatment of various diseases such as cancer, epilepsy, hepatitis C, HIV infection, and Alzheimer’s disease. In drugs they can play a role in drug- target interaction or improve the biological activity of parent molecules. In prodrugs they are mainly used to delay first-pass metabolism and enhance the bioavailability and effectiveness of compounds. This brief review takes a look at the properties and use of carbamates in various fields of medicine and provides quick insights into the mechanisms of action for some of them.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
IP-2018-01-7683 - Analiza interakcija butirilkolinesteraze s novim inhibitorima i reaktivatorima (AnalyseBChE) (Kovarik, Zrinka, HRZZ - 2018-01) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Ana Matošević (autor)

Avatar Url Anita Bosak (autor)


Citiraj ovu publikaciju

Matošević, Ana; Bosak, Anita
Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents // Arhiv za higijenu rada i toksikologiju, 71 (2020), 4; 285-299 (međunarodna recenzija, pregledni rad, ostalo)
Matošević, A. & Bosak, A. (2020) Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents. Arhiv za higijenu rada i toksikologiju, 71 (4), 285-299.
@article{article, year = {2020}, pages = {285-299}, keywords = {anticonvulsants, antiepileptics, cholinesterase inhibitors, neurodegenerative diseases, prodrugs, protease inhibitors}, journal = {Arhiv za higijenu rada i toksikologiju}, volume = {71}, number = {4}, issn = {0004-1254}, title = {Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents}, keyword = {anticonvulsants, antiepileptics, cholinesterase inhibitors, neurodegenerative diseases, prodrugs, protease inhibitors} }
@article{article, year = {2020}, pages = {285-299}, keywords = {anticonvulsants, antiepileptics, cholinesterase inhibitors, neurodegenerative diseases, prodrugs, protease inhibitors}, journal = {Arhiv za higijenu rada i toksikologiju}, volume = {71}, number = {4}, issn = {0004-1254}, title = {Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents}, keyword = {anticonvulsants, antiepileptics, cholinesterase inhibitors, neurodegenerative diseases, prodrugs, protease inhibitors} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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