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Pregled bibliografske jedinice broj: 1115998

Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene


Colacino, Evelina; Porcheddu, Andrea; Halasz, Ivan; Charnay, Clarence; Delogu, Francesco; Guerra, Ruben; Fullenwarth, Julien
Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene // Green chemistry, 20 (2018), 13; 2973-2977 doi:10.1039/c8gc01345d (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1115998 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene

Autori
Colacino, Evelina ; Porcheddu, Andrea ; Halasz, Ivan ; Charnay, Clarence ; Delogu, Francesco ; Guerra, Ruben ; Fullenwarth, Julien

Izvornik
Green chemistry (1463-9262) 20 (2018), 13; 2973-2977

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dantrolene ; nitrofurantoin ; green-metrics ; solvent-free ; mechanochemcal

Sažetak
The eco-compatible, base- and waste-free, energy-efficient, low-environmental-impact, gram-scale, mechanochemical preparation of marketed drugs such as nitrofurantoin (Furantin), dantrolene(Dantrium) and their structurally related derivatives is herein reported. Not a drop of organic solvent was used for the entire process and high yields of pure compounds were obtained without post-reaction work-up. Hydrazones were stable in the presence of water and gaseous HCl, formed as by-products during the synthesis. Comparative mechanochemical experiments were per-formed using diverse milling devices and jar materials, the active pharmaceutical ingredients were analyzed by PXRD and green metrics are calculated.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ivan Halasz (autor)

Citiraj ovu publikaciju

Colacino, Evelina; Porcheddu, Andrea; Halasz, Ivan; Charnay, Clarence; Delogu, Francesco; Guerra, Ruben; Fullenwarth, Julien
Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene // Green chemistry, 20 (2018), 13; 2973-2977 doi:10.1039/c8gc01345d (međunarodna recenzija, članak, znanstveni)
Colacino, E., Porcheddu, A., Halasz, I., Charnay, C., Delogu, F., Guerra, R. & Fullenwarth, J. (2018) Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene. Green chemistry, 20 (13), 2973-2977 doi:10.1039/c8gc01345d.
@article{article, year = {2018}, pages = {2973-2977}, DOI = {10.1039/c8gc01345d}, keywords = {dantrolene, nitrofurantoin, green-metrics, solvent-free, mechanochemcal}, journal = {Green chemistry}, doi = {10.1039/c8gc01345d}, volume = {20}, number = {13}, issn = {1463-9262}, title = {Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene}, keyword = {dantrolene, nitrofurantoin, green-metrics, solvent-free, mechanochemcal} }
@article{article, year = {2018}, pages = {2973-2977}, DOI = {10.1039/c8gc01345d}, keywords = {dantrolene, nitrofurantoin, green-metrics, solvent-free, mechanochemcal}, journal = {Green chemistry}, doi = {10.1039/c8gc01345d}, volume = {20}, number = {13}, issn = {1463-9262}, title = {Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene}, keyword = {dantrolene, nitrofurantoin, green-metrics, solvent-free, mechanochemcal} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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