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Pregled bibliografske jedinice broj: 1114511

Dishevelled family proteins (DVL1-3) expression in IUGR placentas


Sola, Ida Marija; Serman, Alan; Karin- Kujundzic, Valentina; Paic, Frane; Skrtic, Anita; Slatina, Paula; Kakarigi, Luka; Vranic, Semir; Serman, Ljiljana
Dishevelled family proteins (DVL1-3) expression in IUGR placentas // Bosnian journal of basic medical sciences, 21 (2021), 4; 447-453 doi:10.17305/bjbms.2020.5422 (međunarodna recenzija, članak, znanstveni)


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Naslov
Dishevelled family proteins (DVL1-3) expression in IUGR placentas

Autori
Sola, Ida Marija ; Serman, Alan ; Karin- Kujundzic, Valentina ; Paic, Frane ; Skrtic, Anita ; Slatina, Paula ; Kakarigi, Luka ; Vranic, Semir ; Serman, Ljiljana

Izvornik
Bosnian journal of basic medical sciences (1512-8601) 21 (2021), 4; 447-453

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Intrauterine growth restriction ; Placenta ; Dishevelled family proteins ; DVL1 ; DVL2 ; DVL3
(intrauterine growth restriction ; placenta ; Dishevelled family proteins ; DVL1 ; DVL2 ; DVL3)

Sažetak
Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic proteins that are involved in canonical and non-canonical Wnt signaling pathway during embryonic development. The role of DVL proteins in the placental tissue remains mostly unknown. In the current study, we explored the role of Dishevelled proteins in naturally invasive tissue, trophoblast. Formalin-fixed paraffin-embedded samples of 15 term placentas from physiologic term pregnancies and 15 term placentas from pregnancies complicated with intrauterine growth restrictions (IUGR) were used for the study. Expression levels of mRNA for DVL1, DVL2, and DVL3 in placentas were analyzed by quantitative real-time PCR (qRT-PCR). DVL1, DVL2, and DVL3 protein expression were semi- quantitatively analyzed using immunohistochemistry. The expression of DVL3 protein was significantly higher in trophoblasts and endothelial cells in placental villi from IUGR pregnancies compared with the control group of term placentas, while DVL2 protein expression was significantly higher in trophoblasts in placental villi from IUGR pregnancies compared with normal term placentas. The observed differences at protein levels between normal and IUGR placentas were not confirmed at the mRNA levels of DVL genes. Our data indicate the active involvement of DVL proteins in IUGR-related placentas. No significant changes were observed in DVL mRNA levels between the two groups of placentas. Further studies are required to explore the clinical relevance of these observations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinička bolnica "Merkur",
Medicinski fakultet, Zagreb,
Klinička bolnica "Sveti Duh"

Citiraj ovu publikaciju:

Sola, Ida Marija; Serman, Alan; Karin- Kujundzic, Valentina; Paic, Frane; Skrtic, Anita; Slatina, Paula; Kakarigi, Luka; Vranic, Semir; Serman, Ljiljana
Dishevelled family proteins (DVL1-3) expression in IUGR placentas // Bosnian journal of basic medical sciences, 21 (2021), 4; 447-453 doi:10.17305/bjbms.2020.5422 (međunarodna recenzija, članak, znanstveni)
Sola, I., Serman, A., Karin- Kujundzic, V., Paic, F., Skrtic, A., Slatina, P., Kakarigi, L., Vranic, S. & Serman, L. (2021) Dishevelled family proteins (DVL1-3) expression in IUGR placentas. Bosnian journal of basic medical sciences, 21 (4), 447-453 doi:10.17305/bjbms.2020.5422.
@article{article, author = {Sola, Ida Marija and Serman, Alan and Karin- Kujundzic, Valentina and Paic, Frane and Skrtic, Anita and Slatina, Paula and Kakarigi, Luka and Vranic, Semir and Serman, Ljiljana}, year = {2021}, pages = {447-453}, DOI = {10.17305/bjbms.2020.5422}, keywords = {Intrauterine growth restriction, Placenta, Dishevelled family proteins, DVL1, DVL2, DVL3}, journal = {Bosnian journal of basic medical sciences}, doi = {10.17305/bjbms.2020.5422}, volume = {21}, number = {4}, issn = {1512-8601}, title = {Dishevelled family proteins (DVL1-3) expression in IUGR placentas}, keyword = {Intrauterine growth restriction, Placenta, Dishevelled family proteins, DVL1, DVL2, DVL3} }
@article{article, author = {Sola, Ida Marija and Serman, Alan and Karin- Kujundzic, Valentina and Paic, Frane and Skrtic, Anita and Slatina, Paula and Kakarigi, Luka and Vranic, Semir and Serman, Ljiljana}, year = {2021}, pages = {447-453}, DOI = {10.17305/bjbms.2020.5422}, keywords = {intrauterine growth restriction, placenta, Dishevelled family proteins, DVL1, DVL2, DVL3}, journal = {Bosnian journal of basic medical sciences}, doi = {10.17305/bjbms.2020.5422}, volume = {21}, number = {4}, issn = {1512-8601}, title = {Dishevelled family proteins (DVL1-3) expression in IUGR placentas}, keyword = {intrauterine growth restriction, placenta, Dishevelled family proteins, DVL1, DVL2, DVL3} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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