Naslov
Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy

Autori
Sović, Irena ; Lukin, Stipe ; Meštrović, Ernest ; Halasz, Ivan ; Porcheddu, Andrea ; Delogu, Francesco ; Ricci, Pier Carlo ; Caron, Fabien ; Perilli, Thomas ; Dogan, Anita ; Colacino, Evelina

Izvornik
ACS Omega (2470-1343) 5 (2020), 44; 28663-28672

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ammonia ; Raman spectroscopy ; Chemical reactions ; Pharmaceuticals : Silver

Sažetak
The mechanochemical preparation of silver sulfadiazine and dantrolene, two marketed active pharmaceutical ingredients, was investigated by in situ Raman spectroscopy. For the first time, the mechanochemical transformations involving highly fluorescent compounds could be studied in situ with a high- resolution Raman system combined with a unique suitable Raman probe. Moreover, the kinetic features of the mechanochemical process were examined by a mathematical model allowing to describe the chemical changes under mechanical stress. This approach is promising both to broaden the scope of Raman in situ investigations that would otherwise be impossible and for process optimization at any scale.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA