Pregled bibliografske jedinice broj: 1113352
Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy
Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy // ACS Omega, 5 (2020), 44; 28663-28672 doi:10.1021/acsomega.0c03756 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1113352 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy
Autori
Sović, Irena ; Lukin, Stipe ; Meštrović, Ernest ; Halasz, Ivan ; Porcheddu, Andrea ; Delogu, Francesco ; Ricci, Pier Carlo ; Caron, Fabien ; Perilli, Thomas ; Dogan, Anita ; Colacino, Evelina
Izvornik
ACS Omega (2470-1343) 5
(2020), 44;
28663-28672
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Ammonia ; Raman spectroscopy ; Chemical reactions ; Pharmaceuticals : Silver
Sažetak
The mechanochemical preparation of silver sulfadiazine and dantrolene, two marketed active pharmaceutical ingredients, was investigated by in situ Raman spectroscopy. For the first time, the mechanochemical transformations involving highly fluorescent compounds could be studied in situ with a high- resolution Raman system combined with a unique suitable Raman probe. Moreover, the kinetic features of the mechanochemical process were examined by a mathematical model allowing to describe the chemical changes under mechanical stress. This approach is promising both to broaden the scope of Raman in situ investigations that would otherwise be impossible and for process optimization at any scale.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Farmacija
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
