Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy (CROSBI ID 291380)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Sović, Irena ; Lukin, Stipe ; Meštrović, Ernest ; Halasz, Ivan ; Porcheddu, Andrea ; Delogu, Francesco ; Ricci, Pier Carlo ; Caron, Fabien ; Perilli, Thomas ; Dogan, Anita ; Colacino, Evelina
engleski
Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy
The mechanochemical preparation of silver sulfadiazine and dantrolene, two marketed active pharmaceutical ingredients, was investigated by in situ Raman spectroscopy. For the first time, the mechanochemical transformations involving highly fluorescent compounds could be studied in situ with a high- resolution Raman system combined with a unique suitable Raman probe. Moreover, the kinetic features of the mechanochemical process were examined by a mathematical model allowing to describe the chemical changes under mechanical stress. This approach is promising both to broaden the scope of Raman in situ investigations that would otherwise be impossible and for process optimization at any scale.
Ammonia ; Raman spectroscopy ; Chemical reactions ; Pharmaceuticals : Silver
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