Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems (CROSBI ID 291183)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vazdar, Katarina ; Škulj, Sanja ; Bakarić, Danijela ; Margetić, Davor ; Vazdar, Mario
engleski
Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems
Among many reactive oxygen species (ROS) which are constantly generated during oxidative stress in cellular membranes, formation and subsequent reactivity of ubiquitous 4-hydroxy- 2-nonenal (HNE) with nearby amino acids and lipids represents one of the main research targets in cell physiology in the last decades. Starting from the first synthesis of HNE in 1967, chemistry and reactivity of HNE are constantly under intense scrutiny. This review shows recent advances in the field which are discussed with the special emphasis on revealing intricate details of numerous reaction mechanisms of HNE with lipids and amino acids, with the goal of understanding the reactivity of HNE at the molecular level.
4-hydroxy-2-nonenal ; oxidative stress ; covalent modifications ; model biological systems ; reaction mechanism ; lipid modification ; protein modification
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Podaci o izdanju
21 (12)
2021.
1394-1405
objavljeno
1389-5575
1875-5607
10.2174/1389557521666210105110538