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Pregled bibliografske jedinice broj: 1112491

Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems


Vazdar, Katarina; Škulj, Sanja; Bakarić, Danijela; Margetić, Davor; Vazdar, Mario
Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems // Mini-reviews in medicinal chemistry, 21 (2021), 12; 1394-1405 doi:10.2174/1389557521666210105110538 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1112491 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems

Autori
Vazdar, Katarina ; Škulj, Sanja ; Bakarić, Danijela ; Margetić, Davor ; Vazdar, Mario

Izvornik
Mini-reviews in medicinal chemistry (1389-5575) 21 (2021), 12; 1394-1405

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
4-hydroxy-2-nonenal ; oxidative stress ; covalent modifications ; model biological systems ; reaction mechanism ; lipid modification ; protein modification

Sažetak
Among many reactive oxygen species (ROS) which are constantly generated during oxidative stress in cellular membranes, formation and subsequent reactivity of ubiquitous 4-hydroxy- 2-nonenal (HNE) with nearby amino acids and lipids represents one of the main research targets in cell physiology in the last decades. Starting from the first synthesis of HNE in 1967, chemistry and reactivity of HNE are constantly under intense scrutiny. This review shows recent advances in the field which are discussed with the special emphasis on revealing intricate details of numerous reaction mechanisms of HNE with lipids and amino acids, with the goal of understanding the reactivity of HNE at the molecular level.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
UIP-2014-09-6090 - Molekularni aspekti oksidativnih procesa u stanicama (MolOxStress) (Vazdar, Mario, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi www.eurekaselect.com

Citiraj ovu publikaciju:

Vazdar, Katarina; Škulj, Sanja; Bakarić, Danijela; Margetić, Davor; Vazdar, Mario
Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems // Mini-reviews in medicinal chemistry, 21 (2021), 12; 1394-1405 doi:10.2174/1389557521666210105110538 (međunarodna recenzija, članak, znanstveni)
Vazdar, K., Škulj, S., Bakarić, D., Margetić, D. & Vazdar, M. (2021) Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems. Mini-reviews in medicinal chemistry, 21 (12), 1394-1405 doi:10.2174/1389557521666210105110538.
@article{article, author = {Vazdar, Katarina and \v{S}kulj, Sanja and Bakari\'{c}, Danijela and Margeti\'{c}, Davor and Vazdar, Mario}, year = {2021}, pages = {1394-1405}, DOI = {10.2174/1389557521666210105110538}, keywords = {4-hydroxy-2-nonenal, oxidative stress, covalent modifications, model biological systems, reaction mechanism, lipid modification, protein modification}, journal = {Mini-reviews in medicinal chemistry}, doi = {10.2174/1389557521666210105110538}, volume = {21}, number = {12}, issn = {1389-5575}, title = {Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems}, keyword = {4-hydroxy-2-nonenal, oxidative stress, covalent modifications, model biological systems, reaction mechanism, lipid modification, protein modification} }
@article{article, author = {Vazdar, Katarina and \v{S}kulj, Sanja and Bakari\'{c}, Danijela and Margeti\'{c}, Davor and Vazdar, Mario}, year = {2021}, pages = {1394-1405}, DOI = {10.2174/1389557521666210105110538}, keywords = {4-hydroxy-2-nonenal, oxidative stress, covalent modifications, model biological systems, reaction mechanism, lipid modification, protein modification}, journal = {Mini-reviews in medicinal chemistry}, doi = {10.2174/1389557521666210105110538}, volume = {21}, number = {12}, issn = {1389-5575}, title = {Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems}, keyword = {4-hydroxy-2-nonenal, oxidative stress, covalent modifications, model biological systems, reaction mechanism, lipid modification, protein modification} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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