Pregled bibliografske jedinice broj: 1112491
Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems
Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems // Mini-reviews in medicinal chemistry, 21 (2021), 12; 1394-1405 doi:10.2174/1389557521666210105110538 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1112491 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Chemistry and Reactivity of 4-hydroxy-2-nonenal
(HNE) in Model Biological Systems
Autori
Vazdar, Katarina ; Škulj, Sanja ; Bakarić, Danijela ; Margetić, Davor ; Vazdar, Mario
Izvornik
Mini-reviews in medicinal chemistry (1389-5575) 21
(2021), 12;
1394-1405
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
4-hydroxy-2-nonenal ; oxidative stress ; covalent modifications ; model biological systems ; reaction mechanism ; lipid modification ; protein modification
Sažetak
Among many reactive oxygen species (ROS) which are constantly generated during oxidative stress in cellular membranes, formation and subsequent reactivity of ubiquitous 4-hydroxy- 2-nonenal (HNE) with nearby amino acids and lipids represents one of the main research targets in cell physiology in the last decades. Starting from the first synthesis of HNE in 1967, chemistry and reactivity of HNE are constantly under intense scrutiny. This review shows recent advances in the field which are discussed with the special emphasis on revealing intricate details of numerous reaction mechanisms of HNE with lipids and amino acids, with the goal of understanding the reactivity of HNE at the molecular level.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
UIP-2014-09-6090 - Molekularni aspekti oksidativnih procesa u stanicama (MolOxStress) (Vazdar, Mario, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Sanja Škulj
(autor)
Katarina Vazdar
(autor)
Mario Vazdar
(autor)
Danijela Bakarić
(autor)
Davor Margetić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE