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LC-MS/MS profiles and in vitro biological activities of extracts of an endemic species from Turkey: Stachys cretica ssp. anatolica

Genus Stachys is one of the largest of Lamiaceae family, having around 300 different plant species inhabiting areas with temperate and warm climate. The Stachys species in Turkey are represented with 81 taxa ; 51 of them are being endemic. Plants of Stachys genus, have been known on their biological activity and their use in ethnomedicine. This study has proven that the aqueous and methanol extracts of S. cretica ssp. anatolica have prominent antioxidant activity, due to a high amount of polyphenols. The dominant components of S. cretica ssp. anatolica aqueous and methanol extracts, studied with LC-MS/MS technique were: chlorogenic acid, apigenin-7- glucoside and verbascoside. The prominent biological activity of the studied S. cretica ssp. anatolica methanol and aqueous extracts showed strong antioxidant activity and inhibition of enzymes tyrosinase and α-amylase, involved in skin disorder and diabetes mellitus type II. The strong antioxidant properties of these extracts can be used for human health benefits. It is evident that S. cretica ssp. anatolica is promising source of the chemical compounds whose application can be found in pharmacy, food and cosmetics industry.

Stachys, antioxidant, phenolics, flavonoids, LC-MS/MS, tyrosinase, α-amylase

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