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Pregled bibliografske jedinice broj: 1111901

Circulating Levels of Dephosphorylated- Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome


Bilalić, Admira; Tičinović Kurir, Tina; Kumrić, Marko; Borovac, Josip Anđelo; Matetić, Andrija; Šupe Domić, Daniela; Božić, Joško
Circulating Levels of Dephosphorylated- Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome // Molecules, 26 (2021), 4; 1-13 doi:10.3390/molecules26041108 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1111901 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Circulating Levels of Dephosphorylated- Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome

Autori
Bilalić, Admira ; Tičinović Kurir, Tina ; Kumrić, Marko ; Borovac, Josip Anđelo ; Matetić, Andrija ; Šupe Domić, Daniela ; Božić, Joško

Izvornik
Molecules (1420-3049) 26 (2021), 4; 1-13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
matrix Gla protein ; acute coronary syndrome ; vascular calcification ; myocardial infarction ; STEMI ; NSTEMI

Sažetak
Vascular calcification contributes to the pathogenesis of coronary artery disease while matrix Gla protein (MGP) was recently identified as a potent inhibitor of vascular calcification. MGP fractions, such as dephosphorylated-uncarboxylated MGP (dp-ucMGP), lack post-translational modifications and are less efficient in vascular calcification inhibition. We sought to compare dp-ucMGP levels between patients with acute coronary syndrome (ACS), stratified by ST-elevation myocardial infarction (STEMI) and non-ST- elevation myocardial infarction (NSTEMI) status. Physical examination and clinical data, along with plasma dp-ucMGP levels, were obtained from 90 consecutive ACS patients. We observed that levels of dp-ucMGP were significantly higher in patients with NSTEMI compared to STEMI patients (1063.4 ± 518.6 vs. 742.7 ± 166.6 pmol/L, p < 0.001). NSTEMI status and positive family history of cardiovascular diseases were only independent predictors of the highest tertile of dp-ucMGP levels. Among those with NSTEMI, patients at a high risk of in-hospital mortality (adjudicated by GRACE score) had significantly higher levels of dp- ucMGP compared to non-high-risk patients (1417.8 ± 956.8 vs. 984.6 ± 335.0 pmol/L, p = 0.030). Altogether, our findings suggest that higher dp-ucMGP levels likely reflect higher calcification burden in ACS patients and might aid in the identification of NSTEMI patients at increased risk of in-hospital mortality. Furthermore, observed dp-ucMGP levels might reflect differences in atherosclerotic plaque pathobiology between patients with STEMI and NSTEMI.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC Split,
Medicinski fakultet, Split

Citiraj ovu publikaciju

Bilalić, Admira; Tičinović Kurir, Tina; Kumrić, Marko; Borovac, Josip Anđelo; Matetić, Andrija; Šupe Domić, Daniela; Božić, Joško
Circulating Levels of Dephosphorylated- Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome // Molecules, 26 (2021), 4; 1-13 doi:10.3390/molecules26041108 (međunarodna recenzija, članak, znanstveni)
Bilalić, A., Tičinović Kurir, T., Kumrić, M., Borovac, J., Matetić, A., Šupe Domić, D. & Božić, J. (2021) Circulating Levels of Dephosphorylated- Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome. Molecules, 26 (4), 1-13 doi:10.3390/molecules26041108.
@article{article, year = {2021}, pages = {1-13}, DOI = {10.3390/molecules26041108}, keywords = {matrix Gla protein, acute coronary syndrome, vascular calcification, myocardial infarction, STEMI, NSTEMI}, journal = {Molecules}, doi = {10.3390/molecules26041108}, volume = {26}, number = {4}, issn = {1420-3049}, title = {Circulating Levels of Dephosphorylated- Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome}, keyword = {matrix Gla protein, acute coronary syndrome, vascular calcification, myocardial infarction, STEMI, NSTEMI} }
@article{article, year = {2021}, pages = {1-13}, DOI = {10.3390/molecules26041108}, keywords = {matrix Gla protein, acute coronary syndrome, vascular calcification, myocardial infarction, STEMI, NSTEMI}, journal = {Molecules}, doi = {10.3390/molecules26041108}, volume = {26}, number = {4}, issn = {1420-3049}, title = {Circulating Levels of Dephosphorylated- Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome}, keyword = {matrix Gla protein, acute coronary syndrome, vascular calcification, myocardial infarction, STEMI, NSTEMI} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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