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Pregled bibliografske jedinice broj: 1111488

Assessment of Steatosis and Fibrosis in Liver Transplant Recipients Using Controlled Attenuation Parameter and Liver Stiffness Measurements


Mikolasevic, Ivana; Hauser, Goran; Mijic, Maja; Domislovic, Viktor; Radic-Kristo, Delfa; Krznaric, Zeljko; Razov-Radas, Melanija; Pavic, Tajana; Matasin, Marija; Filipec Kanizaj, Tajana
Assessment of Steatosis and Fibrosis in Liver Transplant Recipients Using Controlled Attenuation Parameter and Liver Stiffness Measurements // Canadian Journal of Gastroenterology and Hepatology, 2021 (2021), 1-12 doi:10.1155/2021/6657047 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1111488 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Assessment of Steatosis and Fibrosis in Liver Transplant Recipients Using Controlled Attenuation Parameter and Liver Stiffness Measurements

Autori
Mikolasevic, Ivana ; Hauser, Goran ; Mijic, Maja ; Domislovic, Viktor ; Radic-Kristo, Delfa ; Krznaric, Zeljko ; Razov-Radas, Melanija ; Pavic, Tajana ; Matasin, Marija ; Filipec Kanizaj, Tajana

Izvornik
Canadian Journal of Gastroenterology and Hepatology (2291-2789) 2021 (2021); 1-12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Steatosis ; Fibrosis ; Liver transplant

Sažetak
Aim. The primary objective of this study was to evaluate the prevalence of increased controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) as surrogate markers of liver steatosis and fibrosis in liver transplant recipient (LTR). Secondary objectives were to determine the predictors of increased CAP and LSM in population of LTR. Methods. In this prospective, cross-sectional study, we have evaluated 175 LTRs’ mean age as 61 (53–65) with a functioning graft for more than one year who came for regular outpatient examinations to the Department of Gastroenterology, University Hospital (UH) Merkur, Zagreb, Croatia. Results. Of 175 analyzed LTRs, 34.28% had obesity, 64.00% had hypertension, 38.28% had diabetes, and 58.85% had hyperlipidemia. The prevalence of liver steatosis was 68.57%, while the prevalence of severe liver steatosis was 46.85%. On multivariate analysis, independent factors associated with liver steatosis were male gender, total cholesterol as positive predictor, and HDL as negative predictor, and independent factors positively associated with severe liver steatosis were higher body mass index (BMI) and higher triglyceride levels. The prevalence of moderate liver fibrosis was 54.85%, while the prevalence of advanced liver fibrosis was 24%. On multivariate analysis, independent factors positively associated with moderate fibrosis were gamma-glutamyl transferase (GGT) and CAP, while the independent factor positively associated with advanced fibrosis was GGT. Conclusion. Our study showed high prevalence of increased CAP and LSM measurements as surrogate markers of liver steatosis and fibrosis. Metabolic syndrome components were highly present and were associated with CAP and LSM values as well as in the pretransplant setting. Due to high prevalence of metabolic comorbidities and nonalcoholic fatty liver disease in LTRs and the lack of the abnormal liver test in a significant number of these patients, TE with CAP may be a reasonable initial assessment for LTRs with one or more components of the metabolic syndrome.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinička bolnica "Merkur",
Medicinski fakultet, Rijeka,
Opća bolnica Zadar,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb,
Klinički bolnički centar Rijeka,
Sveučilište u Zadru

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi

Citiraj ovu publikaciju:

Mikolasevic, Ivana; Hauser, Goran; Mijic, Maja; Domislovic, Viktor; Radic-Kristo, Delfa; Krznaric, Zeljko; Razov-Radas, Melanija; Pavic, Tajana; Matasin, Marija; Filipec Kanizaj, Tajana
Assessment of Steatosis and Fibrosis in Liver Transplant Recipients Using Controlled Attenuation Parameter and Liver Stiffness Measurements // Canadian Journal of Gastroenterology and Hepatology, 2021 (2021), 1-12 doi:10.1155/2021/6657047 (međunarodna recenzija, članak, znanstveni)
Mikolasevic, I., Hauser, G., Mijic, M., Domislovic, V., Radic-Kristo, D., Krznaric, Z., Razov-Radas, M., Pavic, T., Matasin, M. & Filipec Kanizaj, T. (2021) Assessment of Steatosis and Fibrosis in Liver Transplant Recipients Using Controlled Attenuation Parameter and Liver Stiffness Measurements. Canadian Journal of Gastroenterology and Hepatology, 2021, 1-12 doi:10.1155/2021/6657047.
@article{article, year = {2021}, pages = {1-12}, DOI = {10.1155/2021/6657047}, keywords = {Steatosis, Fibrosis, Liver transplant}, journal = {Canadian Journal of Gastroenterology and Hepatology}, doi = {10.1155/2021/6657047}, volume = {2021}, issn = {2291-2789}, title = {Assessment of Steatosis and Fibrosis in Liver Transplant Recipients Using Controlled Attenuation Parameter and Liver Stiffness Measurements}, keyword = {Steatosis, Fibrosis, Liver transplant} }
@article{article, year = {2021}, pages = {1-12}, DOI = {10.1155/2021/6657047}, keywords = {Steatosis, Fibrosis, Liver transplant}, journal = {Canadian Journal of Gastroenterology and Hepatology}, doi = {10.1155/2021/6657047}, volume = {2021}, issn = {2291-2789}, title = {Assessment of Steatosis and Fibrosis in Liver Transplant Recipients Using Controlled Attenuation Parameter and Liver Stiffness Measurements}, keyword = {Steatosis, Fibrosis, Liver transplant} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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