Is low-level metal exposure related to testicular cancer? (CROSBI ID 290856)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Tariba Lovaković, Blanka ; Živković Semren, Tanja ; Safner, Toni ; Gamulin, Marija ; Soče, Majana ; Pizent, Alica
engleski
Is low-level metal exposure related to testicular cancer?
Disruption of element homeostasis may contribute to increased susceptibility of men to cancer development. Whether environmental low-level metal exposure could contribute to the pathogenesis of testicular cancer is unknown. Comparison of the level of 18 elements in whole blood, serum and urine and parameters of oxidative stress/antioxidant status between men with testicular germ cell tumors (TGCT) and healthy men showed significant difference between the groups in most parameters. The results of linear discriminant analysis with a discrimination rate of 96% indicated whole blood Ca, Co, Cu, Fe, K, Mg, Na and Zn, serum Ca, Cu, Na and Ni, and urine Cd, Co, Fe and Mn being the strongest predictors of illness. TGCT patients had a significant increase in serum and blood Cu and decrease in serum Fe and blood Zn with cancer progression. Significantly higher concentrations of Al, As, Pb, and Ni in whole blood/serum of men with TGCT confirm the hypothesis that low-level environmental exposure to these elements may contribute to cancer development. Relationship between elements concentrations and treatment outcomes should be carefully monitored during cancer treatment since high concentrations of commonly used platinum-based chemotherapeutics may additionally disturb the homeostasis of elements.
testicular cancer ; toxic elements ; oxidative stress ; linear discriminant analysis
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
39 (1)
2021.
87-107
objavljeno
2689-6583
2689-6591
10.1080/26896583.2021.1874234
Povezanost rada
Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti