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Pregled bibliografske jedinice broj: 1110484

The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus


Tomić, Draško; Davidović, Davor; Szasz, Attila Marcel; Rezeli, Melinda; Pirkić, Boris; Petrik, Jozsef; Bačić Vrca, Vesna; Janđel, Vladimir; Lipić, Tomislav; Skala, Karolj et al.
The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus // Informatics in Medicine Unlocked, 23 (2021), 100529, 7 doi:10.1016/j.imu.2021.100529 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1110484 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus

Autori
Tomić, Draško ; Davidović, Davor ; Szasz, Attila Marcel ; Rezeli, Melinda ; Pirkić, Boris ; Petrik, Jozsef ; Bačić Vrca, Vesna ; Janđel, Vladimir ; Lipić, Tomislav ; Skala, Karolj ; Mesarić, Josip ; Milković Periša, Marija ; Šojat, Zorislav ; Medved Rogina, Branka

Izvornik
Informatics in Medicine Unlocked (2352-9148) 23 (2021); 100529, 7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
SARS-CoV-2 spike glycoprotein ; HIV cocktail therapy ; Inhibition efficiency ; Virtual drug screening ; Antiviral drugs ; COVID-19

Sažetak
Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for the treatment of patients with the COVID-19 disease. Because of that, we analyzed the inhibition of SARS-CoV-2 spike glycoprotein with FDA-approved antiviral drugs and their double and triple combinations. We used the Vini in silico model of cancer to perform this virtual drug screening, showing HIV drugs to be the most effective. Besides, the combination of cobicistat-abacavir-rilpivirine HIV drugs demonstrated the highest in silico efficacy of inhibiting SARS-CoV-2 spike glycoprotein. Therefore, a clinical trial of cobicistat-abacavir-rilpivirine on a limited number of COVID-19 patients in moderately severe and severe conditions is warranted.

Izvorni jezik
Engleski

Znanstvena područja
Računarstvo, Interdisciplinarne tehničke znanosti, Biotehnologija



POVEZANOST RADA


Projekti:
EK-KF-KK.01.1.1.01.009 - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (DATACROSS) (Lončarić, Sven; Petrović, Ivan; Šmuc, Tomislav; Jokić, Andrej, EK - KK.01.1.1.01) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Fakultet elektrotehnike i računarstva, Zagreb,
Veterinarski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Tomić, Draško; Davidović, Davor; Szasz, Attila Marcel; Rezeli, Melinda; Pirkić, Boris; Petrik, Jozsef; Bačić Vrca, Vesna; Janđel, Vladimir; Lipić, Tomislav; Skala, Karolj et al.
The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus // Informatics in Medicine Unlocked, 23 (2021), 100529, 7 doi:10.1016/j.imu.2021.100529 (međunarodna recenzija, članak, znanstveni)
Tomić, D., Davidović, D., Szasz, A., Rezeli, M., Pirkić, B., Petrik, J., Bačić Vrca, V., Janđel, V., Lipić, T. & Skala, K. (2021) The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus. Informatics in Medicine Unlocked, 23, 100529, 7 doi:10.1016/j.imu.2021.100529.
@article{article, author = {Tomi\'{c}, Dra\v{s}ko and Davidovi\'{c}, Davor and Szasz, Attila Marcel and Rezeli, Melinda and Pirki\'{c}, Boris and Petrik, Jozsef and Ba\v{c}i\'{c} Vrca, Vesna and Jan\djel, Vladimir and Lipi\'{c}, Tomislav and Skala, Karolj and Mesari\'{c}, Josip and Milkovi\'{c} Peri\v{s}a, Marija and \v{S}ojat, Zorislav and Medved Rogina, Branka}, year = {2021}, pages = {7}, DOI = {10.1016/j.imu.2021.100529}, chapter = {100529}, keywords = {SARS-CoV-2 spike glycoprotein, HIV cocktail therapy, Inhibition efficiency, Virtual drug screening, Antiviral drugs, COVID-19}, journal = {Informatics in Medicine Unlocked}, doi = {10.1016/j.imu.2021.100529}, volume = {23}, issn = {2352-9148}, title = {The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus}, keyword = {SARS-CoV-2 spike glycoprotein, HIV cocktail therapy, Inhibition efficiency, Virtual drug screening, Antiviral drugs, COVID-19}, chapternumber = {100529} }
@article{article, author = {Tomi\'{c}, Dra\v{s}ko and Davidovi\'{c}, Davor and Szasz, Attila Marcel and Rezeli, Melinda and Pirki\'{c}, Boris and Petrik, Jozsef and Ba\v{c}i\'{c} Vrca, Vesna and Jan\djel, Vladimir and Lipi\'{c}, Tomislav and Skala, Karolj and Mesari\'{c}, Josip and Milkovi\'{c} Peri\v{s}a, Marija and \v{S}ojat, Zorislav and Medved Rogina, Branka}, year = {2021}, pages = {7}, DOI = {10.1016/j.imu.2021.100529}, chapter = {100529}, keywords = {SARS-CoV-2 spike glycoprotein, HIV cocktail therapy, Inhibition efficiency, Virtual drug screening, Antiviral drugs, COVID-19}, journal = {Informatics in Medicine Unlocked}, doi = {10.1016/j.imu.2021.100529}, volume = {23}, issn = {2352-9148}, title = {The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus}, keyword = {SARS-CoV-2 spike glycoprotein, HIV cocktail therapy, Inhibition efficiency, Virtual drug screening, Antiviral drugs, COVID-19}, chapternumber = {100529} }

Časopis indeksira:


  • Scopus


Citati:





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