The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus (CROSBI ID 290650)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Tomić, Draško ; Davidović, Davor ; Szasz, Attila Marcel ; Rezeli, Melinda ; Pirkić, Boris ; Petrik, Jozsef ; Bačić Vrca, Vesna ; Janđel, Vladimir ; Lipić, Tomislav ; Skala, Karolj ; Mesarić, Josip ; Milković Periša, Marija ; Šojat, Zorislav ; Medved Rogina, Branka
engleski
The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus
Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for the treatment of patients with the COVID-19 disease. Because of that, we analyzed the inhibition of SARS-CoV-2 spike glycoprotein with FDA-approved antiviral drugs and their double and triple combinations. We used the Vini in silico model of cancer to perform this virtual drug screening, showing HIV drugs to be the most effective. Besides, the combination of cobicistat-abacavir-rilpivirine HIV drugs demonstrated the highest in silico efficacy of inhibiting SARS-CoV-2 spike glycoprotein. Therefore, a clinical trial of cobicistat- abacavir-rilpivirine on a limited number of COVID- 19 patients in moderately severe and severe conditions is warranted.
SARS-CoV-2 spike glycoprotein ; HIV cocktail therapy ; Inhibition efficiency ; Virtual drug screening ; Antiviral drugs ; COVID-19
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