PD-L1 and HSP-70 molecules are part of immunosupressive environment in the deep layer of the lymphocyte predominant breast cancer (LPBC) (CROSBI ID 290554)
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Podaci o odgovornosti
Peterko, AC ; Rajković Molek, K ; Veljković Vujaklija, D ; Zujić Valković, P ; Belac Lovasić, I ; Lovasić, F ;
engleski
PD-L1 and HSP-70 molecules are part of immunosupressive environment in the deep layer of the lymphocyte predominant breast cancer (LPBC)
Background: Tumor infiltrating lymphocytes (TILs) are involved in host imunity against tumor cells. However, in later phases of the disease high TIL infiltration is related to disease progression. Tumor immunogenicity is strongly correlated with the higher tumor mutation burden. Triple negative (TN) and HER-2 enriched breast cancers have the highest immunogenic potential so the aim of our study was to investigate the TIL infiltration and expression of PD-L1, HSP-70 in such tumors.
Breast Cancer
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