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Pregled bibliografske jedinice broj: 1110127

SARS-Cov2 S Protein Features Potential Estrogen Binding Site


Tomasović, Ante; Stanzer, Damir; Svetec, Ivan Krešimir; Svetec Miklenić, Marina
SARS-Cov2 S Protein Features Potential Estrogen Binding Site // Food technology and biotechnology (2021) doi:10.17113/ftb.59.01.21.6820 (znanstveni, prihvaćen)


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Naslov
SARS-Cov2 S Protein Features Potential Estrogen Binding Site

Autori
Tomasović, Ante ; Stanzer, Damir ; Svetec, Ivan Krešimir ; Svetec Miklenić, Marina

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Food technology and biotechnology (2021)

Status rada
Prihvaćen

Ključne riječi
SARS-CoV2 ; coronavirus ; S protein ; estrogen ; estradiol ; estrogen binding site

Sažetak
Research background. During the current SARS- CoV2 pandemic, as well as earlier SARS and MERS epidemics, it has been observed that COVID19- positive women on average tend to have milder symptoms and lower fatality rates than men. There is a number of differences between sexes known to contribute to different immune responses and severity of disease, one being the effect of estrogen via estrogen receptor signaling. We wondered if estrogen might also affect the SARS-CoV2 more directly, perhaps by binding to the surface glycoprotein (S protein) thus possibly reducing its infectivity. Experimental approach. To assess whether there is a possibility for estrogen binding on the SARS-CoV2 S protein we used BLAST and HHpred to compare protein sequences of S protein and human estrogen receptor β, while 3D structures of potential estrogen binding site and active site of estrogen receptor β were visualized and compared using PyMOL. Results and conclusions. By comparing protein sequence of SARS-CoV2 S protein with the human estrogen receptor β, we identified a potential estrogen binding site on S protein and further determined that it also shares notable similarities with the active site of ER β when observed in 3D structure of their respective proteins. As a control, SARS- CoV2 S protein was compared with the human androgen receptor, and no such similarities were found. The potential estrogen binding site is a part of coronavirus S2 superfamily domain, which is involved in host-virus membrane fusion during infection and appears to be conserved throughout theCoronaviridaefamily. Novelty and scientific contribution. This preliminary communication shows that SARS-CoV2 S protein features a potential estrogen binding site. Hopefully, this will prompt a more comprehensive study on the possibilities of estrogen binding on the S protein and the effect this might confer on the virus infectivity.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija



POVEZANOST RADA


Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.ftb.com.hr

Citiraj ovu publikaciju:

Tomasović, Ante; Stanzer, Damir; Svetec, Ivan Krešimir; Svetec Miklenić, Marina
SARS-Cov2 S Protein Features Potential Estrogen Binding Site // Food technology and biotechnology (2021) doi:10.17113/ftb.59.01.21.6820 (znanstveni, prihvaćen)
Tomasović, A., Stanzer, D., Svetec, I. & Svetec Miklenić, M. (2021) SARS-Cov2 S Protein Features Potential Estrogen Binding Site. Prihvaćen za objavljivanje u Food technology and biotechnology. [Preprint] doi:10.17113/ftb.59.01.21.6820.
@unknown{unknown, author = {Tomasovi\'{c}, Ante and Stanzer, Damir and Svetec, Ivan Kre\v{s}imir and Svetec Mikleni\'{c}, Marina}, year = {2021}, DOI = {10.17113/ftb.59.01.21.6820}, keywords = {SARS-CoV2, coronavirus, S protein, estrogen, estradiol, estrogen binding site}, journal = {Food technology and biotechnology}, doi = {10.17113/ftb.59.01.21.6820}, title = {SARS-Cov2 S Protein Features Potential Estrogen Binding Site}, keyword = {SARS-CoV2, coronavirus, S protein, estrogen, estradiol, estrogen binding site} }
@unknown{unknown, author = {Tomasovi\'{c}, Ante and Stanzer, Damir and Svetec, Ivan Kre\v{s}imir and Svetec Mikleni\'{c}, Marina}, year = {2021}, DOI = {10.17113/ftb.59.01.21.6820}, keywords = {SARS-CoV2, coronavirus, S protein, estrogen, estradiol, estrogen binding site}, journal = {Food technology and biotechnology}, doi = {10.17113/ftb.59.01.21.6820}, title = {SARS-Cov2 S Protein Features Potential Estrogen Binding Site}, keyword = {SARS-CoV2, coronavirus, S protein, estrogen, estradiol, estrogen binding site} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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