Naslov
Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease

Autori
Mikolasevic, Ivana ; Domislovic, Viktor ; Klapan, Mia ; Juric, Toni ; Lukic, Andjela ; Krznaric-Zrnic, Irena ; Fuckar-Cupic, Dora ; Stimac, Davor ; Filipec Kanizaj, Tajana ; Krznaric, Zeljko ; Radic-Kristo, Delfa ; Milic, Sandra ; Martinovic, Marko ; Grubesic, Aron ; Grgurevic, Ivica

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Ultrasound in Medicine & Biology (2021)

Status rada
Poslan

Ključne riječi
Fatty Liver ; Proton Density (Concentration) ; Keratin-18

Sažetak
Evaluated the diagnostic accuracy of the controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) measured with either an M or XL probe against liver biopsy (LB) in patients with non-alcoholic fatty liver disease (NAFLD). This study was a cross-sectional prospective study that included 179 NAFLD patients. With a cutoff value for CAP ≥345, we can exclude significant steatosis in 87% (79.4%–92.5%) of our population. With respect to the LSM, the highest accuracy was obtained for F ≥ F3 (area under the receiver operating characteristic curve [AUROC] = 0.98) and F = F4 (AUROC = 0.98). In a multivariable linear regression model, significant predictors influencing LSM were fibrosis stage (β = 2.6, p < 0.001) as a positive predictor and lobular inflammation (β = –0.68, p = 0.04) as a negative predictor, without significant influence after adjustment for CAP and probe type. We found that CAP is a satisfactory method for excluding advanced steatosis, while LSM is a good non-invasive marker for the exclusion of fibrosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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