Pregled bibliografske jedinice broj: 1109951
Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease
Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease // Ultrasound in Medicine & Biology (2021) doi:10.1016/j.ultrasmedbio.2020.11.015 (znanstveni, poslan)
CROSBI ID: 1109951 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Accuracy of Controlled Attenuation Parameter
and Liver Stiffness Measurement in Patients
with Non-alcoholic Fatty Liver Disease
Autori
Mikolasevic, Ivana ; Domislovic, Viktor ; Klapan, Mia ; Juric, Toni ; Lukic, Andjela ; Krznaric-Zrnic, Irena ; Fuckar-Cupic, Dora ; Stimac, Davor ; Filipec Kanizaj, Tajana ; Krznaric, Zeljko ; Radic-Kristo, Delfa ; Milic, Sandra ; Martinovic, Marko ; Grubesic, Aron ; Grgurevic, Ivica
Vrsta, podvrsta
Radovi u časopisima,
znanstveni
Izvornik
Ultrasound in Medicine & Biology (2021)
Status rada
Poslan
Ključne riječi
Fatty Liver ; Proton Density (Concentration) ; Keratin-18
Sažetak
Evaluated the diagnostic accuracy of the controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) measured with either an M or XL probe against liver biopsy (LB) in patients with non-alcoholic fatty liver disease (NAFLD). This study was a cross-sectional prospective study that included 179 NAFLD patients. With a cutoff value for CAP ≥345, we can exclude significant steatosis in 87% (79.4%–92.5%) of our population. With respect to the LSM, the highest accuracy was obtained for F ≥ F3 (area under the receiver operating characteristic curve [AUROC] = 0.98) and F = F4 (AUROC = 0.98). In a multivariable linear regression model, significant predictors influencing LSM were fibrosis stage (β = 2.6, p < 0.001) as a positive predictor and lobular inflammation (β = –0.68, p = 0.04) as a negative predictor, without significant influence after adjustment for CAP and probe type. We found that CAP is a satisfactory method for excluding advanced steatosis, while LSM is a good non-invasive marker for the exclusion of fibrosis.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka
Profili:
Aron Grubešić
(autor)
Ivana Mikolašević
(autor)
Davor Štimac
(autor)
Delfa Radić Krišto
(autor)
Željko Krznarić
(autor)
Tajana Filipec Kanižaj
(autor)
Irena Krznarić-Zrnić
(autor)
Ivica Grgurević
(autor)
Dora Fučkar Čupić
(autor)
Sandra Milić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE