Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease (CROSBI ID 290488)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Mikolaševic, Ivana ; Domislović, Viktor ; Klapan, Mia ; Jurić, Toni ; Lukić, Anđela ; Krznarić-Zrnić, Irena ; Fučkar Čupić, Dora ; Štimac, Davor ; Filipec Kanižaj, Tajana ; Krznarić, Željko ; RadiĆ-KriŠto, Delfa ; Milić, Sandra ; Martinović, Marko ; Grubešić, Aron ; Grgurević, Ivica
engleski
Accuracy of Controlled Attenuation Parameter and Liver Stiffness Measurement in Patients with Non-alcoholic Fatty Liver Disease
evaluated the diagnostic accuracy of the controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) measured with either an M or XL probe against liver biopsy (LB) in patients with non- alcoholic fatty liver disease (NAFLD). This study was a cross-sectional prospective study that included 179 NAFLD patients. With a cutoff value for CAP ≥345, we can exclude significant steatosis in 87% (79.4%– 92.5%) of our population. With respect to the LSM, the highest accuracy was obtained for F ≥ F3 (area under the receiver operating characteristic curve [AUROC] = 0.98) and F = F4 (AUROC = 0.98). In a multivariable linear regression model, significant predictors influencing LSM were fibrosis stage (β = 2.6, p < 0.001) as a positive predictor and lobular inflammation (β = –0.68, p = 0.04) as a negative predictor, without significant influence after adjustment for CAP and probe type. We found that CAP is a satisfactory method for excluding advanced steatosis, while LSM is a good non-invasive marker for the exclusion of fibrosis.
Fatty Liver ; Proton Density (Concentration) ; Keratin-18
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Podaci o izdanju
47 (3)
2021.
428-437
objavljeno
0301-5629
10.1016/j.ultrasmedbio.2020.11.015
Povezanost rada
Kliničke medicinske znanosti