Lipofilnost lijekova. I dio : Važnost lipofilnosti u istraživanju novih lijekova (CROSBI ID 80168)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Medić-Šarić, Marica ; Franić, Danijela ; Debeljak, Željko
hrvatski
Lipofilnost lijekova. I dio : Važnost lipofilnosti u istraživanju novih lijekova
nije evidentirano
lipofilnost; koeficijent razdiobe; log P; Hanschova metoda; Rekkerova metoda; shake flask metoda
Lipophilicity is a prime physicochemical descriptor of xenobiotics with relevance to their biological properties. The hydrophobic interaction of drugs with a receptor and the toxicological properties are examples of a steadily increasing number of topics in which lipophilicity plays an important role. A number of theoretical and empirical approaches have been developed during the last twenty years for calculation of Log P values. The most common experimental method for determining the equilibria of drugs partitioning between water and n-octanol is shake flask method. In this context calculative approaches are superior to experimental procedures.
engleski
Lipophilicity of drugs. Part I
nije evidentirano
lipophilicity; partition coefficient; log P; Hansch's method; Rekker's method; shake flask method
nije evidentirano