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Pregled bibliografske jedinice broj: 1107737

Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires


Babić, Sanja; Čižmek, Lara; Maršavelski, Aleksandra; Malev, Olga; Pflieger, Maryline; Strunjak-Perović, Ivančica; Topić Popović, Natalija; Čož-Rakovac, Rozelindra; Trebše, Polonca
Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires // Scientific reports, 11 (2021), 2527, 12 doi:10.1038/s41598-021-81789-1 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1107737 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires

Autori
Babić, Sanja ; Čižmek, Lara ; Maršavelski, Aleksandra ; Malev, Olga ; Pflieger, Maryline ; Strunjak-Perović, Ivančica ; Topić Popović, Natalija ; Čož-Rakovac, Rozelindra ; Trebše, Polonca

Izvornik
Scientific reports (2045-2322) 11 (2021); 2527, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
biomass burning ; methoxyphenols ; nitrated intermediates ; atmospheric pollution ; zebrafish embryotoxicity

Sažetak
Amazonian wildfires in 2019 have raised awareness about rainforest burning due to increased emissions of particulate matter and carbon. In the context of these emissions, by-products of lignin thermal degradation (i.e. methoxyphenols) are often neglected. Methoxyphenols entering the atmosphere may form intermediates with currently unknown reaction mechanisms and toxicity. This study for the first time provides a comprehensive insight into the impact of lignin degradation products [guaiacol, catechol], and their nitrated intermediates [4-nitrocatechol, 4, 6- dinitroguaiacol, 5-nitroguaiacol] on zebrafish Danio rerio. Results revealed 4-nitrocatechol and catechol as the most toxic, followed by 4, 6DNG > 5NG > GUA. The whole-organism bioassay integrated with molecular modeling emphasized the potential of methoxyphenols to inhibit tyrosinase, lipoxygenase, and carbonic anhydrase, consequently altering embryonic development (i.e. affected sensorial, skeletal, and physiological parameters, pigmentation formation failure, and non-hatching of larvae). The whole-organism bioassay integrated with in silico approach confirmed the harmful effects of lignin degradation products and their intermediates on aquatic organisms, emphasizing the need for their evaluation within ecotoxicity studies focused on aquatic compartments.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Biotehnologija



POVEZANOST RADA


Projekti:
EK-KF-KK.01.1.1.01.0002 - Bioprospecting Jadranskog mora (Čož-Rakovac, Rozelinda; Dragović-Uzelac, Verica; Šantek, Božidar; Jokić, Stela; Jerković, Igor; Kraljević Pavelić, Sandra, EK - KK.01.1.1.01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Babić, Sanja; Čižmek, Lara; Maršavelski, Aleksandra; Malev, Olga; Pflieger, Maryline; Strunjak-Perović, Ivančica; Topić Popović, Natalija; Čož-Rakovac, Rozelindra; Trebše, Polonca
Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires // Scientific reports, 11 (2021), 2527, 12 doi:10.1038/s41598-021-81789-1 (međunarodna recenzija, članak, znanstveni)
Babić, S., Čižmek, L., Maršavelski, A., Malev, O., Pflieger, M., Strunjak-Perović, I., Topić Popović, N., Čož-Rakovac, R. & Trebše, P. (2021) Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires. Scientific reports, 11, 2527, 12 doi:10.1038/s41598-021-81789-1.
@article{article, year = {2021}, pages = {12}, DOI = {10.1038/s41598-021-81789-1}, chapter = {2527}, keywords = {biomass burning, methoxyphenols, nitrated intermediates, atmospheric pollution, zebrafish embryotoxicity}, journal = {Scientific reports}, doi = {10.1038/s41598-021-81789-1}, volume = {11}, issn = {2045-2322}, title = {Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires}, keyword = {biomass burning, methoxyphenols, nitrated intermediates, atmospheric pollution, zebrafish embryotoxicity}, chapternumber = {2527} }
@article{article, year = {2021}, pages = {12}, DOI = {10.1038/s41598-021-81789-1}, chapter = {2527}, keywords = {biomass burning, methoxyphenols, nitrated intermediates, atmospheric pollution, zebrafish embryotoxicity}, journal = {Scientific reports}, doi = {10.1038/s41598-021-81789-1}, volume = {11}, issn = {2045-2322}, title = {Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires}, keyword = {biomass burning, methoxyphenols, nitrated intermediates, atmospheric pollution, zebrafish embryotoxicity}, chapternumber = {2527} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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