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Pregled bibliografske jedinice broj: 1107646

Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high- level athletes


Briški, Nina; Vrgoč, Goran; Knjaz, Damir; Janković, Saša; Ivković, Alan; Pećina, Marko; Lauc, Gordan
Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high- level athletes // International Orthopaedics, 1 (2020), 1, 6 doi:10.1007/s00264-020-04684-w (međunarodna recenzija, članak, znanstveni)


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Naslov
Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high- level athletes

Autori
Briški, Nina ; Vrgoč, Goran ; Knjaz, Damir ; Janković, Saša ; Ivković, Alan ; Pećina, Marko ; Lauc, Gordan

Izvornik
International Orthopaedics (0341-2695) 1 (2020); 1, 6

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Matrix metalloproteinase 3 (MMP3) ; Single nucleotide polymorphism ; Genetic association study ; Achilles tendinopathy ; Sport injury

Sažetak
Abstract Background Matrix metalloproteinases (MMPs) play an important role in matrix remodelling, as well as in tendon integrity. Due to overuse, athletes often develop chronic tendinopathies. If not treated, they lead to severe impairment, even complete tendon ruptures. Aim The main purpose of this study was to investigate whether three functional polymorphisms within the MMP3 gene are associated with increased risk of developing tendinopathies in high-level Croatian athletes. Methods We have recruited one hundred fifty- five (63 high-level athletes with diagnosed tendinopathies and 92 asymptomatic controls) unrelated Caucasians for this case- control genetic study. All participants were genotyped for three single nucleotide polymorphisms (SNP) within the MMP3 gene: rs591058 C/T, rs650108 A/G and rs679620 G/A using the pyrosequencing method. Results The MMP3 rs650108 GG (P = 0.0074) and rs679620 AA (P = 0.0119) genotypes were significantly over-represented in cases compared with controls, while rs591058 TT (P = 0.0759), as well as haplotype variant T - G - A (P = 0.06), implicated that there is an indication of predisposition for tendinopathies. Conclusion These results support association between functional variants within the MMP3 gene and the risk of tendinopathies in high-level athletes. Further research is needed to replicate these results in a larger population.

Izvorni jezik
Engleski

Znanstvena područja
Kineziologija



POVEZANOST RADA


Ustanove:
Kineziološki fakultet, Zagreb

Profili:

Avatar Url Goran Vrgoč (autor)

Avatar Url Gordan Lauc (autor)

Avatar Url Alan Ivković (autor)

Avatar Url Saša Janković (autor)

Avatar Url Marko Pećina (autor)

Avatar Url Damir Knjaz (autor)

Citiraj ovu publikaciju

Briški, Nina; Vrgoč, Goran; Knjaz, Damir; Janković, Saša; Ivković, Alan; Pećina, Marko; Lauc, Gordan
Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high- level athletes // International Orthopaedics, 1 (2020), 1, 6 doi:10.1007/s00264-020-04684-w (međunarodna recenzija, članak, znanstveni)
Briški, N., Vrgoč, G., Knjaz, D., Janković, S., Ivković, A., Pećina, M. & Lauc, G. (2020) Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high- level athletes. International Orthopaedics, 1, 1, 6 doi:10.1007/s00264-020-04684-w.
@article{article, year = {2020}, pages = {6}, DOI = {10.1007/s00264-020-04684-w}, chapter = {1}, keywords = {Matrix metalloproteinase 3 (MMP3), Single nucleotide polymorphism, Genetic association study, Achilles tendinopathy, Sport injury}, journal = {International Orthopaedics}, doi = {10.1007/s00264-020-04684-w}, volume = {1}, issn = {0341-2695}, title = {Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high- level athletes}, keyword = {Matrix metalloproteinase 3 (MMP3), Single nucleotide polymorphism, Genetic association study, Achilles tendinopathy, Sport injury}, chapternumber = {1} }
@article{article, year = {2020}, pages = {6}, DOI = {10.1007/s00264-020-04684-w}, chapter = {1}, keywords = {Matrix metalloproteinase 3 (MMP3), Single nucleotide polymorphism, Genetic association study, Achilles tendinopathy, Sport injury}, journal = {International Orthopaedics}, doi = {10.1007/s00264-020-04684-w}, volume = {1}, issn = {0341-2695}, title = {Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high- level athletes}, keyword = {Matrix metalloproteinase 3 (MMP3), Single nucleotide polymorphism, Genetic association study, Achilles tendinopathy, Sport injury}, chapternumber = {1} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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