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Pregled bibliografske jedinice broj: 1106183

Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin


Gašperov, Jana; Mikulandra, Ivana; Jednačak, Tomislav; Bertoša, Branimir; Habinovec, Iva; Novak, Predrag
Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin // Adriatic NMR Conference : Book of Abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena (ur.).
Zagreb: Department of Chemistry, Faculty of Science, 2020. str. 41-41 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1106183 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin

Autori
Gašperov, Jana ; Mikulandra, Ivana ; Jednačak, Tomislav ; Bertoša, Branimir ; Habinovec, Iva ; Novak, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR Conference : Book of Abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Department of Chemistry, Faculty of Science, 2020, 41-41

ISBN
978-953-6076-58-1

Skup
Adriatic NMR Conference 2020.

Mjesto i datum
Peroj, Hrvatska, 22-24.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
macrozones ; synthesis ; structure ; characterization

Sažetak
Azithromycin belongs to macrolide class of antibiotics wich exert its biological activity by binding to bacterial ribosome at or near the peptidyl transferase center thus inhibiting protein biosynthesis. They are effective in treating infections caused by Gram-positive and some Gram-negative bacteria. Due to the increased development of bacterial resistance much effort is directed towards the discovery of new more potent antibiotics. A series of bioactive azithromycin derivatives, the new class of macrozones have been prepared by coupling thiosemicarbazones to azithromycin at position 4" (Figure 1). Here we present their synthesis, characterization and interactions of macrozone precursor, 4"-aminopropyl azithromycin with the ribosome isolated from E. Coli. A combination of NMR experiments such as saturation transfer difference (STD) and transferred nuclear Overhauser effect spectroscopy (trNOESY) and molecular modeling were applied to determine binding epitopes and explore bound conformations.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-8098 - Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije (Makrozoni/Macrozones) (Novak, Predrag, HRZZ - 2018-01) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Gašperov, Jana; Mikulandra, Ivana; Jednačak, Tomislav; Bertoša, Branimir; Habinovec, Iva; Novak, Predrag
Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin // Adriatic NMR Conference : Book of Abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena (ur.).
Zagreb: Department of Chemistry, Faculty of Science, 2020. str. 41-41 (poster, domaća recenzija, sažetak, znanstveni)
Gašperov, J., Mikulandra, I., Jednačak, T., Bertoša, B., Habinovec, I. & Novak, P. (2020) Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin. U: Bregović, N., Namjesnik, D., Novak, P. & Parlov Vuković, J. (ur.)Adriatic NMR Conference : Book of Abstracts.
@article{article, year = {2020}, pages = {41-41}, keywords = {macrozones, synthesis, structure, characterization}, isbn = {978-953-6076-58-1}, title = {Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin}, keyword = {macrozones, synthesis, structure, characterization}, publisher = {Department of Chemistry, Faculty of Science}, publisherplace = {Peroj, Hrvatska} }
@article{article, year = {2020}, pages = {41-41}, keywords = {macrozones, synthesis, structure, characterization}, isbn = {978-953-6076-58-1}, title = {Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin}, keyword = {macrozones, synthesis, structure, characterization}, publisher = {Department of Chemistry, Faculty of Science}, publisherplace = {Peroj, Hrvatska} }




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