Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin (CROSBI ID 699095)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Gašperov, Jana ; Mikulandra, Ivana ; Jednačak, Tomislav ; Bertoša, Branimir ; Habinovec, Iva ; Novak, Predrag
engleski
Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin
Azithromycin belongs to macrolide class of antibiotics wich exert its biological activity by binding to bacterial ribosome at or near the peptidyl transferase center thus inhibiting protein biosynthesis. They are effective in treating infections caused by Gram-positive and some Gram-negative bacteria. Due to the increased development of bacterial resistance much effort is directed towards the discovery of new more potent antibiotics. A series of bioactive azithromycin derivatives, the new class of macrozones have been prepared by coupling thiosemicarbazones to azithromycin at position 4" (Figure 1). Here we present their synthesis, characterization and interactions of macrozone precursor, 4"-aminopropyl azithromycin with the ribosome isolated from E. Coli. A combination of NMR experiments such as saturation transfer difference (STD) and transferred nuclear Overhauser effect spectroscopy (trNOESY) and molecular modeling were applied to determine binding epitopes and explore bound conformations.
macrozones ; synthesis ; structure ; characterization
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Podaci o prilogu
41-41.
2020.
objavljeno
Podaci o matičnoj publikaciji
Adriatic NMR Conference : Book of Abstracts
Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena
Zagreb: Kemijski odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu ; Geološki odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu
978-953-6076-58-1
Podaci o skupu
4th Adriatic NMR conference 2020
poster
22.09.2020-24.09.2020
Peroj, Hrvatska; Vodnjan, Hrvatska