Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1104907

Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions


Čanadi-Jurešić, Gordana; Ćurko-Cofek, Božena; Barbarić, Martina; Mumiši, Nermina; Blagović, Branka; Jamnik, Polona
Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions // Current microbiology (2021) (znanstveni, prihvaćen)


CROSBI ID: 1104907 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions

Autori
Čanadi-Jurešić, Gordana ; Ćurko-Cofek, Božena ; Barbarić, Martina ; Mumiši, Nermina ; Blagović, Branka ; Jamnik, Polona

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Current microbiology (2021)

Status rada
Prihvaćen

Ključne riječi
yeast ; stress response ; metal toxicity ; mitochondrial proteome

Sažetak
Yeast Saccharomyces cerevisiae is an ideal model organism for studying molecular mechanisms of the stress response provoked by metals. In this work, yeast cells response to iron (Fe3+) or lead (Pb2+) exposure was tested and compared. Survival test was used to determine testing doses of metal ions – for Fe3+ it was 4 mM and for Pb2+ 8mM. These (high, over-loaded) doses provoked comparable values of growth inhibition, but different values in vitality measurement. The percentage of metabolically active cells, determined by fluorescent FUN-1 dye, was lower in Pb2+ than in Fe3+ treated cells. Besides, endogenous antioxidant defence systems in the cells treated with Pb2+ were less efficient compared to Fe3+. At the mitochondrial level, the effects of metal ions were in correlation with the results of cell metabolic activity. The mitochondrial proteome of Pb2+ treated cells showed the domination of protein down- regulation. Yeast cells treated either with Fe3+ or Pb2+ shared 19 common significantly changed proteins. The affected proteins were involved in different cellular process and among them only five proteins belong to energy and carbohydrate metabolism, and protein biosynthesis. Based on all obtained results, it is possible to conclude that the effects of Fe3+ and Pb2+ on yeast cells show rather specific patterns of toxicity and stress response.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Čanadi-Jurešić, Gordana; Ćurko-Cofek, Božena; Barbarić, Martina; Mumiši, Nermina; Blagović, Branka; Jamnik, Polona
Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions // Current microbiology (2021) (znanstveni, prihvaćen)
Čanadi-Jurešić, G., Ćurko-Cofek, B., Barbarić, M., Mumiši, N., Blagović, B. & Jamnik, P. (2021) Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions. Prihvaćen za objavljivanje u Current microbiology. [Preprint].
@unknown{unknown, year = {2021}, keywords = {yeast, stress response, metal toxicity, mitochondrial proteome}, journal = {Current microbiology}, title = {Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions}, keyword = {yeast, stress response, metal toxicity, mitochondrial proteome} }
@unknown{unknown, year = {2021}, keywords = {yeast, stress response, metal toxicity, mitochondrial proteome}, journal = {Current microbiology}, title = {Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions}, keyword = {yeast, stress response, metal toxicity, mitochondrial proteome} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font