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Pregled bibliografske jedinice broj: 1104731

Sex differences in oncogenic mutational processes


(The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium) Li, Constance H.; PCAWG Tumour Subtypes and Clinical Translation; Prokopec, Stephenie D.; Sun, Ren X.; Yousif, Fouad; Schmitz, Nathaniel; Boutros, Paul C.; PCAWG Consortium
Sex differences in oncogenic mutational processes // Nature communications, 11 (2020), 1; 1-24 doi:10.1038/s41467-020-17359-2 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1104731 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Sex differences in oncogenic mutational processes

Autori
Li, Constance H. ; PCAWG Tumour Subtypes and Clinical Translation ; Prokopec, Stephenie D. ; Sun, Ren X. ; Yousif, Fouad ; Schmitz, Nathaniel ; Boutros, Paul C. ; PCAWG Consortium

Kolaboracija
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium

Izvornik
Nature communications (2041-1723) 11 (2020), 1; 1-24

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cancer genetics ; Cancer genomics ; Genome informatics ; Oncogenes

Sažetak
Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( POIROT)
EK-KF-KK.01.1.1.01.0010 - ZCI za personaliziranu brigu o zdravlju (ZCIPersonHealth) (Secenji, Aleksandar, EK ) ( POIROT)
EK-KF-KK.01.1.1.01.009 - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (DATACROSS) (Lončarić, Sven; Ivan, Petrović, EK - KK.01.1.1.01) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Rosa Karlić (autor)

Citiraj ovu publikaciju

(The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium) Li, Constance H.; PCAWG Tumour Subtypes and Clinical Translation; Prokopec, Stephenie D.; Sun, Ren X.; Yousif, Fouad; Schmitz, Nathaniel; Boutros, Paul C.; PCAWG Consortium
Sex differences in oncogenic mutational processes // Nature communications, 11 (2020), 1; 1-24 doi:10.1038/s41467-020-17359-2 (međunarodna recenzija, članak, znanstveni)
(The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium) (The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium) Li, C., PCAWG Tumour Subtypes and Clinical Translation, Prokopec, S., Sun, R., Yousif, F., Schmitz, N., Boutros, P. & PCAWG Consortium (2020) Sex differences in oncogenic mutational processes. Nature communications, 11 (1), 1-24 doi:10.1038/s41467-020-17359-2.
@article{article, year = {2020}, pages = {1-24}, DOI = {10.1038/s41467-020-17359-2}, keywords = {Cancer genetics, Cancer genomics, Genome informatics, Oncogenes}, journal = {Nature communications}, doi = {10.1038/s41467-020-17359-2}, volume = {11}, number = {1}, issn = {2041-1723}, title = {Sex differences in oncogenic mutational processes}, keyword = {Cancer genetics, Cancer genomics, Genome informatics, Oncogenes} }
@article{article, year = {2020}, pages = {1-24}, DOI = {10.1038/s41467-020-17359-2}, keywords = {Cancer genetics, Cancer genomics, Genome informatics, Oncogenes}, journal = {Nature communications}, doi = {10.1038/s41467-020-17359-2}, volume = {11}, number = {1}, issn = {2041-1723}, title = {Sex differences in oncogenic mutational processes}, keyword = {Cancer genetics, Cancer genomics, Genome informatics, Oncogenes} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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