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Sex differences in oncogenic mutational processes (CROSBI ID 288963)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

(The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium) Li, Constance H. ; PCAWG Tumour Subtypes and Clinical Translation ; Prokopec, Stephenie D. ; Sun, Ren X. ; Yousif, Fouad ; Schmitz, Nathaniel ; Boutros, Paul C. ; PCAWG Consortium Sex differences in oncogenic mutational processes // Nature communications, 11 (2020), 1; 1-24. doi: 10.1038/s41467-020-17359-2

Podaci o odgovornosti

Li, Constance H. ; PCAWG Tumour Subtypes and Clinical Translation ; Prokopec, Stephenie D. ; Sun, Ren X. ; Yousif, Fouad ; Schmitz, Nathaniel ; Boutros, Paul C. ; PCAWG Consortium

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium

engleski

Sex differences in oncogenic mutational processes

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.

Cancer genetics ; Cancer genomics ; Genome informatics ; Oncogenes

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Podaci o izdanju

11 (1)

2020.

1-24

objavljeno

2041-1723

10.1038/s41467-020-17359-2

Povezanost rada

Biologija

Poveznice
Indeksiranost