engleski

Xeromeds consortium: The impact of medications on stimulated and unstimulated salivary flow rate in patients with Sjögren's Syndrome

Objective: To evaluate the impact of categories of and specific medications on unstimulated whole salivary flow rate (UWSFR) and stimulated whole salivary flow rate (SWSFR) in patients with Sjögren’s Syndrome (SS). Material and methods: This was a multi-center, retrospective, observational study collecting data from six international centers. Data collected from 2010- 2014 for all patients included age, gender, UWSFR and SWSFR, categories of and specific medications. Results: Of all 302 patients, 294 (94.0%) were females and 18 (6.0%) were males. The age of all patients was 56.4 ± 12.9 (mean ± SD) years. Collectively, the patients had a daily intake of 4.8 ± 4.5 different medications and had a mean UWSFR of 1.42 ± 2.21 ml/15min and a mean SWSFR of 9.40 ± 14.06 mL/15min. Among the most frequent categories of medications, only antihypertensives were associated with lower UWSFR (p<0.017) and vitamins (p=0.050) were associated with higher SWSFR. Among the most frequent single medication, vitamin D (p= 0.028) and multivitamins (p<0.001) were associated with higher SWSFR. Patients taking medications had higher SWSFR (p = 0.024), but no difference in UWSFR (p= 0.985) than patients who did not take any medication. No correlation was found between UWSFR and SWSFR and the number of medications. Conclusions: Certain and commonly prescribed medications, but not the number of medications, may have an additional negative impact on UWSFR or SWSFR in patients with SS. Overall, SS patients taking medications have higher SWSFR than those not taking medications. Certain vitamins may have a positive impact on salivary flow in SS.

xerostomia ; Sjögren's Syndrome ; medications ; salivary flow rate

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