engleski

SOX2 reveals a stem cell potential in the human fetal subplate

Cortical organization is established by orchestrated spatio-temporal histogenetic and neurogenetic processes regulated by differential gene expression. During fetal corticogenesis, critical step happens in the proliferative ventricular (VZ) and subventricular (SVZ) zone, where neurons are born from stem cells and other progenitors. SOX2 is a transcription factor responsible for upholding the identity of neural stem cells, therefore represents a key player during corticogenesis. The aim of our study was to identify stem cells and cells with proliferative capacity in the human non- proliferative, synaptic subplate during midgestation, by utilizing double labelling immunofluorescence. Interestingly enough, our results show shifts in the SOX2 expression pattern from proliferative zones at midgestation. Furthermore, during the late mid- fetal period, SOX2 was sparsely distributed throughout the subplate, whose neurodevelopmental role remains elusive.

human fetal cerebral cortex ; SOX2 ; neural stem cells

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