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Pregled bibliografske jedinice broj: 1103711

Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial


Kraljević Pavelić, Sandra; Micek, Vedran; Bobinac, Dragica; Bazdulj, Edo; Gianoncelli, Alessandra; Krpan, Dalibor; Žuvić, Marta; Eisenwagen, Sandra; Stambrook, Peter J; Pavelić, Krešimir
Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial // Experimental biology and medicine, 246 (2020), 529-537 doi:10.1177/1535370220968752 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1103711 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial

Autori
Kraljević Pavelić, Sandra ; Micek, Vedran ; Bobinac, Dragica ; Bazdulj, Edo ; Gianoncelli, Alessandra ; Krpan, Dalibor ; Žuvić, Marta ; Eisenwagen, Sandra ; Stambrook, Peter J ; Pavelić, Krešimir

Izvornik
Experimental biology and medicine (1535-3702) 246 (2020); 529-537

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Zeolite ; clinoptilolite tuff ; clinoptilolite Panaceo Micro Activation ; osteoporosis ; ovariectomized rats ; double-blinded clinical trial

Sažetak
The severity of osteoporosis in humans manifests in its high incidence and by its complications that diminish quality of life. A societal consequence of osteoporosis is the substantial burden that it inflicts upon patients and their families. Several bone-modifying drugs have been prescribed to patients with osteoporosis. However, evidence for their antifracture efficacy remains inconclusive. To the contrary, long-term use of anti-osteoporotic drugs such as bisphosphonates and Denosumab, an RANKL inhibitor, have resulted in adverse events. We now present an alternative and adjuvant approach for treatment of osteoporosis. The data derive from in vivo studies in an ovariectomized rat model and from a randomized double blind, placebo-controlled human clinical study. Both studies involved treatment with Panaceo Micro Activation (PMA)-zeolite-clinoptilolite, a defined cation exchange clinoptilolite, which clearly improved all bone histomorphometric parameters examined from ovariectomized animals, indicative for increased bone formation. Moreover, intervention with PMA-zeolite-clinoptilolite for one year proved safe in humans. Furthermore, patients treated with PMA-zeolite-clinoptilolite showed an increase in bone mineral density, an elevated level of markers indicative of bone formation, a significant reduction in pain, and significantly improved quality of life compared with patients in the control (placebo) group. These encouraging positive effects of PMA-zeolite-clinoptilolite on bone integrity and on osteoporosis warrant further evaluation of treatment with PMA-zeolite-clinoptilolite as a new alternative adjuvant therapy for osteoporosis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Sveučilište Jurja Dobrile u Puli,
Sveučilište u Rijeci,
Fakultet zdravstvenih studija u Rijeci

Poveznice na cjeloviti tekst rada:

doi journals.sagepub.com doi.org

Citiraj ovu publikaciju:

Kraljević Pavelić, Sandra; Micek, Vedran; Bobinac, Dragica; Bazdulj, Edo; Gianoncelli, Alessandra; Krpan, Dalibor; Žuvić, Marta; Eisenwagen, Sandra; Stambrook, Peter J; Pavelić, Krešimir
Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial // Experimental biology and medicine, 246 (2020), 529-537 doi:10.1177/1535370220968752 (međunarodna recenzija, članak, znanstveni)
Kraljević Pavelić, S., Micek, V., Bobinac, D., Bazdulj, E., Gianoncelli, A., Krpan, D., Žuvić, M., Eisenwagen, S., Stambrook, P. & Pavelić, K. (2020) Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial. Experimental biology and medicine, 246, 529-537 doi:10.1177/1535370220968752.
@article{article, author = {Kraljevi\'{c} Paveli\'{c}, Sandra and Micek, Vedran and Bobinac, Dragica and Bazdulj, Edo and Gianoncelli, Alessandra and Krpan, Dalibor and \v{Z}uvi\'{c}, Marta and Eisenwagen, Sandra and Stambrook, Peter J and Paveli\'{c}, Kre\v{s}imir}, year = {2020}, pages = {529-537}, DOI = {10.1177/1535370220968752}, keywords = {Zeolite, clinoptilolite tuff, clinoptilolite Panaceo Micro Activation, osteoporosis, ovariectomized rats, double-blinded clinical trial}, journal = {Experimental biology and medicine}, doi = {10.1177/1535370220968752}, volume = {246}, issn = {1535-3702}, title = {Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial}, keyword = {Zeolite, clinoptilolite tuff, clinoptilolite Panaceo Micro Activation, osteoporosis, ovariectomized rats, double-blinded clinical trial} }
@article{article, author = {Kraljevi\'{c} Paveli\'{c}, Sandra and Micek, Vedran and Bobinac, Dragica and Bazdulj, Edo and Gianoncelli, Alessandra and Krpan, Dalibor and \v{Z}uvi\'{c}, Marta and Eisenwagen, Sandra and Stambrook, Peter J and Paveli\'{c}, Kre\v{s}imir}, year = {2020}, pages = {529-537}, DOI = {10.1177/1535370220968752}, keywords = {Zeolite, clinoptilolite tuff, clinoptilolite Panaceo Micro Activation, osteoporosis, ovariectomized rats, double-blinded clinical trial}, journal = {Experimental biology and medicine}, doi = {10.1177/1535370220968752}, volume = {246}, issn = {1535-3702}, title = {Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial}, keyword = {Zeolite, clinoptilolite tuff, clinoptilolite Panaceo Micro Activation, osteoporosis, ovariectomized rats, double-blinded clinical trial} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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