engleski

Ternary palladium(II) complexes with N- benzyliminodiacetic acid derivatives and 2,2′- bipyridine: Preparation, thermogravimetric, vibrational spectroscopic, DFT, NMR studies and biological activity in vitro

The reactions of N-benzyliminodiacetic acid (BnidaH2) and its para-substituted derivatives, namely: N-(p-chlorobenzyl)iminodiacetic acid (p- ClBnidaH2), N-(p-nitrobenzyl)iminodiacetic acid (p-NO2BnidaH2) and N-(p- methoxybenzyl)iminodiacetic acid (p-MeOBnidaH2) with paladium(II) chloride and 2, 2′-bipyridine, were performed in water-acetonitrile solutions. Four new prepared complexes [Pd(Bnida)(bipy)]∙2H2O (1), [Pd(p-ClBnida)(bipy)]∙4H2O (2), [Pd(p- NO2Bnida)(bipy)]∙2H2O (3) and [Pd(p-MeOBnida) (bipy)]∙3H2O (4) were identified by means of chemical analysis and mass spectrometry, and characterized by infrared spectroscopy and thermal analysis (TG/DTA). The molecular geometry and infrared spectra of these four complexes were modelled using DFT calculations at the BP86/def2- TZVP (Pd: ECP) level of theory. Extensive NMR studies have shown the presence of two isomers in solution (DMSO). The characterized palladium(II) complexes demonstrate valuable antiproliferative activity against Caco-2, SW620, NCI-H358 and MDCK I reducing cell growth from 71.7% to 79.9% (10−4 M) (1 ; 4). PANC-1 display mild sensitivity and slow reduction in cell growth (less than 50%) while BJ present higher viability range and proliferative status. BJ proliferation after exposure to palladium complexes at 10−4 M concentration ranged from 55.2% to 83.5% (1–4). In descending order, antiproliferative effect of tested palladium complexes is, as follows: 4 > 1 > 2 > 3.

Palladium complexes ; Iminodiacetic acid derivatives ; IR spectroscopy ; Density functional theory calculations ; Nuclear magnetic resonance ; Antitumor activity

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