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Pregled bibliografske jedinice broj: 1103675

Ternary palladium(II) complexes with N- benzyliminodiacetic acid derivatives and 2,2′- bipyridine: Preparation, thermogravimetric, vibrational spectroscopic, DFT, NMR studies and biological activity in vitro


Popović, Zora; Smrečki, Neven; Jović, Ozren; Mišković Špoljarić, Katarina; Gašo-Sokač, Dajana; Bušić, Valentina; Roca, Sunčica; Marković, Berislav
Ternary palladium(II) complexes with N- benzyliminodiacetic acid derivatives and 2,2′- bipyridine: Preparation, thermogravimetric, vibrational spectroscopic, DFT, NMR studies and biological activity in vitro // Inorganica chimica acta, 516 (2021), 120131, 9 doi:10.1016/j.ica.2020.120131 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1103675 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Ternary palladium(II) complexes with N- benzyliminodiacetic acid derivatives and 2,2′- bipyridine: Preparation, thermogravimetric, vibrational spectroscopic, DFT, NMR studies and biological activity in vitro

Autori
Popović, Zora ; Smrečki, Neven ; Jović, Ozren ; Mišković Špoljarić, Katarina ; Gašo-Sokač, Dajana ; Bušić, Valentina ; Roca, Sunčica ; Marković, Berislav

Izvornik
Inorganica chimica acta (0020-1693) 516 (2021); 120131, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Palladium complexes ; Iminodiacetic acid derivatives ; IR spectroscopy ; Density functional theory calculations ; Nuclear magnetic resonance ; Antitumor activity

Sažetak
The reactions of N-benzyliminodiacetic acid (BnidaH2) and its para-substituted derivatives, namely: N-(p-chlorobenzyl)iminodiacetic acid (p- ClBnidaH2), N-(p-nitrobenzyl)iminodiacetic acid (p-NO2BnidaH2) and N-(p- methoxybenzyl)iminodiacetic acid (p-MeOBnidaH2) with paladium(II) chloride and 2, 2′-bipyridine, were performed in water-acetonitrile solutions. Four new prepared complexes [Pd(Bnida)(bipy)]∙2H2O (1), [Pd(p-ClBnida)(bipy)]∙4H2O (2), [Pd(p- NO2Bnida)(bipy)]∙2H2O (3) and [Pd(p-MeOBnida) (bipy)]∙3H2O (4) were identified by means of chemical analysis and mass spectrometry, and characterized by infrared spectroscopy and thermal analysis (TG/DTA). The molecular geometry and infrared spectra of these four complexes were modelled using DFT calculations at the BP86/def2- TZVP (Pd: ECP) level of theory. Extensive NMR studies have shown the presence of two isomers in solution (DMSO). The characterized palladium(II) complexes demonstrate valuable antiproliferative activity against Caco-2, SW620, NCI-H358 and MDCK I reducing cell growth from 71.7% to 79.9% (10−4 M) (1 ; 4). PANC-1 display mild sensitivity and slow reduction in cell growth (less than 50%) while BJ present higher viability range and proliferative status. BJ proliferation after exposure to palladium complexes at 10−4 M concentration ranged from 55.2% to 83.5% (1–4). In descending order, antiproliferative effect of tested palladium complexes is, as follows: 4 > 1 > 2 > 3.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prehrambeno-tehnološki fakultet, Osijek,
Prirodoslovno-matematički fakultet, Zagreb,
Medicinski fakultet, Osijek,
Sveučilište u Osijeku - Odjel za kemiju,
Sveučilište u Zagrebu,
Sveučilište J. J. Strossmayera u Osijeku

Citiraj ovu publikaciju

Popović, Zora; Smrečki, Neven; Jović, Ozren; Mišković Špoljarić, Katarina; Gašo-Sokač, Dajana; Bušić, Valentina; Roca, Sunčica; Marković, Berislav
Ternary palladium(II) complexes with N- benzyliminodiacetic acid derivatives and 2,2′- bipyridine: Preparation, thermogravimetric, vibrational spectroscopic, DFT, NMR studies and biological activity in vitro // Inorganica chimica acta, 516 (2021), 120131, 9 doi:10.1016/j.ica.2020.120131 (međunarodna recenzija, članak, znanstveni)
Popović, Z., Smrečki, N., Jović, O., Mišković Špoljarić, K., Gašo-Sokač, D., Bušić, V., Roca, S. & Marković, B. (2021) Ternary palladium(II) complexes with N- benzyliminodiacetic acid derivatives and 2,2′- bipyridine: Preparation, thermogravimetric, vibrational spectroscopic, DFT, NMR studies and biological activity in vitro. Inorganica chimica acta, 516, 120131, 9 doi:10.1016/j.ica.2020.120131.
@article{article, year = {2021}, pages = {9}, DOI = {10.1016/j.ica.2020.120131}, chapter = {120131}, keywords = {Palladium complexes, Iminodiacetic acid derivatives, IR spectroscopy, Density functional theory calculations, Nuclear magnetic resonance, Antitumor activity}, journal = {Inorganica chimica acta}, doi = {10.1016/j.ica.2020.120131}, volume = {516}, issn = {0020-1693}, title = {Ternary palladium(II) complexes with N- benzyliminodiacetic acid derivatives and 2,2′- bipyridine: Preparation, thermogravimetric, vibrational spectroscopic, DFT, NMR studies and biological activity in vitro}, keyword = {Palladium complexes, Iminodiacetic acid derivatives, IR spectroscopy, Density functional theory calculations, Nuclear magnetic resonance, Antitumor activity}, chapternumber = {120131} }
@article{article, year = {2021}, pages = {9}, DOI = {10.1016/j.ica.2020.120131}, chapter = {120131}, keywords = {Palladium complexes, Iminodiacetic acid derivatives, IR spectroscopy, Density functional theory calculations, Nuclear magnetic resonance, Antitumor activity}, journal = {Inorganica chimica acta}, doi = {10.1016/j.ica.2020.120131}, volume = {516}, issn = {0020-1693}, title = {Ternary palladium(II) complexes with N- benzyliminodiacetic acid derivatives and 2,2′- bipyridine: Preparation, thermogravimetric, vibrational spectroscopic, DFT, NMR studies and biological activity in vitro}, keyword = {Palladium complexes, Iminodiacetic acid derivatives, IR spectroscopy, Density functional theory calculations, Nuclear magnetic resonance, Antitumor activity}, chapternumber = {120131} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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