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Pregled bibliografske jedinice broj: 1102408

Crystal structure of 9-deoxo-9a-aza-9a-N-(p- bromobenzoyl)-8,9- didehydro-6-deoxy-6,9-epoxy- 9a-homoerythronolide A


Nagl, Ante; Mrvoš-Sermek, Draginja; Kamenar, Boris; Kobrehel, Gabrijela
Crystal structure of 9-deoxo-9a-aza-9a-N-(p- bromobenzoyl)-8,9- didehydro-6-deoxy-6,9-epoxy- 9a-homoerythronolide A // Zeitschrift fur Kristallographie, 211 (1996), 427-428 (međunarodna recenzija, članak, znanstveni)


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Naslov
Crystal structure of 9-deoxo-9a-aza-9a-N-(p- bromobenzoyl)-8,9- didehydro-6-deoxy-6,9-epoxy- 9a-homoerythronolide A

Autori
Nagl, Ante ; Mrvoš-Sermek, Draginja ; Kamenar, Boris ; Kobrehel, Gabrijela

Izvornik
Zeitschrift fur Kristallographie (2194-4946) 211 (1996); 427-428

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
crystal structure, 15-membered macrolide antibiotic, derivatives

Sažetak
Source of material: Erythromycin A 6, 9-imino ether is an intermediate in the synthesis of azithromycin. This synthesis is based on an acid catalysed cleavage of both sugars of erythromycin A 6, 9-imino ether followed by the condensation of aglycone with p- bromobenzoylchloride. Since in the refinement there were not observed any conformational differences between the three independent molecules in the super-structure, the structure was refined in the subcell a'=a/3, b'=b, c'=c, ß'=ß. The conformation of the aglycone ring is consistent with the analogous azalide derivatives except in the region of the 6, 9- epoxy plane (refs. 1 and 2). C28H40BrNO8, monoclinic, P21 (No. 4), a =10.647(6) Â, b=6.991(6) A, c =20.913(8) A, ß =109.24(3)°, V= 1469.7 A3, Z=2, R(F) =0.048, Rw(F) =0.048.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Ustanove:
Pliva-Istraživački institut,
Prirodoslovno-matematički fakultet, Zagreb


Citiraj ovu publikaciju

Nagl, Ante; Mrvoš-Sermek, Draginja; Kamenar, Boris; Kobrehel, Gabrijela
Crystal structure of 9-deoxo-9a-aza-9a-N-(p- bromobenzoyl)-8,9- didehydro-6-deoxy-6,9-epoxy- 9a-homoerythronolide A // Zeitschrift fur Kristallographie, 211 (1996), 427-428 (međunarodna recenzija, članak, znanstveni)
Nagl, A., Mrvoš-Sermek, D., Kamenar, B. & Kobrehel, G. (1996) Crystal structure of 9-deoxo-9a-aza-9a-N-(p- bromobenzoyl)-8,9- didehydro-6-deoxy-6,9-epoxy- 9a-homoerythronolide A. Zeitschrift fur Kristallographie, 211, 427-428.
@article{article, year = {1996}, pages = {427-428}, keywords = {crystal structure, 15-membered macrolide antibiotic, derivatives}, journal = {Zeitschrift fur Kristallographie}, volume = {211}, issn = {2194-4946}, title = {Crystal structure of 9-deoxo-9a-aza-9a-N-(p- bromobenzoyl)-8,9- didehydro-6-deoxy-6,9-epoxy- 9a-homoerythronolide A}, keyword = {crystal structure, 15-membered macrolide antibiotic, derivatives} }
@article{article, year = {1996}, pages = {427-428}, keywords = {crystal structure, 15-membered macrolide antibiotic, derivatives}, journal = {Zeitschrift fur Kristallographie}, volume = {211}, issn = {2194-4946}, title = {Crystal structure of 9-deoxo-9a-aza-9a-N-(p- bromobenzoyl)-8,9- didehydro-6-deoxy-6,9-epoxy- 9a-homoerythronolide A}, keyword = {crystal structure, 15-membered macrolide antibiotic, derivatives} }




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