engleski

Complexes of Azithromycin with Some Divalent Metal Ions

The formation of 2 : 1 complexes of azithromycin with copper(II), zinc(II), cobalt(II), nickel(II), magnesium(II) and calcium(II) ions was examined. These compounds (2-7) showed the same in vitro biological potency as azithromycin (1). The complexes (3- 7) are isostructural and different when compared with azithromycin-Cu(II)- complex. Copper(II)-complex (2) was most stable and selected for structure determination by X-ray crystallography. Some physical characteristics and analyses of the complexes are also presented.

azithromycin, metal complexes

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