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Pregled bibliografske jedinice broj: 1102384

Crystal structure of four solvates of lorazepam with ethanol (A), acetone (B), dioxane (C) and cyclohexanone (D)


Kamenar, Boris; Mrvoš-Sermek, Draginja; Nagl, Ante.
Crystal structure of four solvates of lorazepam with ethanol (A), acetone (B), dioxane (C) and cyclohexanone (D) // Croatica Chemica Acta, 62 (1989), 505-513 (međunarodna recenzija, članak, znanstveni)


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Naslov
Crystal structure of four solvates of lorazepam with ethanol (A), acetone (B), dioxane (C) and cyclohexanone (D)

Autori
Kamenar, Boris ; Mrvoš-Sermek, Draginja ; Nagl, Ante.

Izvornik
Croatica Chemica Acta (0011-1643) 62 (1989); 505-513

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
lorazepam, solvates, crystal structure

Sažetak
X-ray structure analysis of four solvates of lorazepam with ethanol (A), acetone (B), dioxane (C) and cyclohexanone (D) is described. All four crystallize in the triclinic system, space group P1, and with the lorazepam molecules of essentially the same conformation. As common in other benzodiazepines, the seven- membered rings adopt a boat conformation. The four solvates have different kinds of hydrogen bonding. While in (A), (B) and (D) lorazepam molecules are interconnected either by N-H...O (282 to 292 pm) or O-H...O hydrogen bonds (289 pm) in (C) such bonding does not exist. The solvent molecules fill cavities in the crystal structures and are linked to the lorazepam molecules either by van der Waals interactions as in (A), (B) and (C) or by hydrogen bond of the O-H...O type of 281 pm in (D). The investigated structures are compared with other lorazepam derivatives and solvates previously described in the literature.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Ustanove:
Tekstilno-tehnološki fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Antun Nagl (autor)

Avatar Url Draginja Mrvoš-Sermek (autor)

Avatar Url Boris Kamenar (autor)

Citiraj ovu publikaciju

Kamenar, Boris; Mrvoš-Sermek, Draginja; Nagl, Ante.
Crystal structure of four solvates of lorazepam with ethanol (A), acetone (B), dioxane (C) and cyclohexanone (D) // Croatica Chemica Acta, 62 (1989), 505-513 (međunarodna recenzija, članak, znanstveni)
Kamenar, B., Mrvoš-Sermek, D. & Nagl, A. (1989) Crystal structure of four solvates of lorazepam with ethanol (A), acetone (B), dioxane (C) and cyclohexanone (D). Croatica Chemica Acta, 62, 505-513.
@article{article, year = {1989}, pages = {505-513}, keywords = {lorazepam, solvates, crystal structure}, journal = {Croatica Chemica Acta}, volume = {62}, issn = {0011-1643}, title = {Crystal structure of four solvates of lorazepam with ethanol (A), acetone (B), dioxane (C) and cyclohexanone (D)}, keyword = {lorazepam, solvates, crystal structure} }
@article{article, year = {1989}, pages = {505-513}, keywords = {lorazepam, solvates, crystal structure}, journal = {Croatica Chemica Acta}, volume = {62}, issn = {0011-1643}, title = {Crystal structure of four solvates of lorazepam with ethanol (A), acetone (B), dioxane (C) and cyclohexanone (D)}, keyword = {lorazepam, solvates, crystal structure} }




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