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Pregled bibliografske jedinice broj: 1102211

Aryl-diyne linkers in bis-triarylborane cations control fluorimetric and Raman sensing of various DNA and RNA


Ferger, Matthias; Ban, Željka; Krošl, Ivona; Tomić, Sanja; Dietrich, Lena; Lorenzen, Sabine; Rauch, Florian; Sieh, Daniel; Friedrich, Alexandra; Griesbeck, Stefaine et al.
Aryl-diyne linkers in bis-triarylborane cations control fluorimetric and Raman sensing of various DNA and RNA // Chemistry : a European journal (2021) (znanstveni, prihvaćen)


CROSBI ID: 1102211 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Aryl-diyne linkers in bis-triarylborane cations control fluorimetric and Raman sensing of various DNA and RNA

Autori
Ferger, Matthias ; Ban, Željka ; Krošl, Ivona ; Tomić, Sanja ; Dietrich, Lena ; Lorenzen, Sabine ; Rauch, Florian ; Sieh, Daniel ; Friedrich, Alexandra ; Griesbeck, Stefaine ; Kenđel, Adriana ; Miljanić, Snežana ; Piantanida, Ivo ; Marder, Todd B.

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Chemistry : a European journal (2021)

Status rada
Prihvaćen

Ključne riječi
Borane ; Fluorescent probe ; Raman probe ; DNA/RNA Sensor ; Molecular Modelling

Sažetak
We report four new luminescent tetracationic bis-triarylborane DNA and RNA sensors that show high binding affinities, in several cases even in the nM range. Three of the compounds contain substituted, highly emissive, and structurally flexible bis(2, 6-dimethylphenyl-4-ethynyl)arene linkers (3: arene = 5, 5’-2, 2’-bithiophene ; 4: arene = 1, 4-benzene ; 5: arene = 9, 10-anthracene) between the two boryl moieties and serve as efficient dual Raman and fluorescence chromophores. The shorter analogue 6 employs bis(2, 6-dimethylphenyl)-9, 10-anthracene as the linker and demonstrates the importance of an adequate linker length with a certain level of flexibility by exhibiting generally lower binding affinities than 3-5. Pronounced aggregation - deaggregation processes are observed in fluorimetric titration experiments with DNA for compounds 3 and 5. Molecular modelling of complexes of 5 with AT-DNA, suggest the minor 2 groove as the dominant binding site for monomeric 5, but demonstrate that dimers of 5 can also be accommodated. Strong SERS responses for 3-5 (particularly compound 5) vs. a very weak response for 6 demonstrate the importance of triple bonds for strong Raman activity in molecules of this compound class. The energy of the characteristic stretching vibration of the C≡C bonds is significantly dependent on the aromatic moiety between the triple bonds. The insertion of aromatic moieties between two C≡C bonds thus offers an alternative design for dual Raman and fluorescence chromophores, applicable in multiplex biological Raman imaging.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
IP-2018-01-5475 - Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina (BioMultiChromoProbes) (Piantanida, Ivo, HRZZ - 2018-01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Ferger, Matthias; Ban, Željka; Krošl, Ivona; Tomić, Sanja; Dietrich, Lena; Lorenzen, Sabine; Rauch, Florian; Sieh, Daniel; Friedrich, Alexandra; Griesbeck, Stefaine et al.
Aryl-diyne linkers in bis-triarylborane cations control fluorimetric and Raman sensing of various DNA and RNA // Chemistry : a European journal (2021) (znanstveni, prihvaćen)
Ferger, M., Ban, Ž., Krošl, I., Tomić, S., Dietrich, L., Lorenzen, S., Rauch, F., Sieh, D., Friedrich, A. & Griesbeck, S. (2021) Aryl-diyne linkers in bis-triarylborane cations control fluorimetric and Raman sensing of various DNA and RNA. Prihvaćen za objavljivanje u Chemistry : a European journal. [Preprint].
@unknown{unknown, year = {2021}, keywords = {Borane, Fluorescent probe, Raman probe, DNA/RNA Sensor, Molecular Modelling}, journal = {Chemistry : a European journal}, title = {Aryl-diyne linkers in bis-triarylborane cations control fluorimetric and Raman sensing of various DNA and RNA}, keyword = {Borane, Fluorescent probe, Raman probe, DNA/RNA Sensor, Molecular Modelling} }
@unknown{unknown, year = {2021}, keywords = {Borane, Fluorescent probe, Raman probe, DNA/RNA Sensor, Molecular Modelling}, journal = {Chemistry : a European journal}, title = {Aryl-diyne linkers in bis-triarylborane cations control fluorimetric and Raman sensing of various DNA and RNA}, keyword = {Borane, Fluorescent probe, Raman probe, DNA/RNA Sensor, Molecular Modelling} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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