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Pregled bibliografske jedinice broj: 1102121

AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers


Mustapić, Mislav; Glumac, Zvonko; Heffer, Marija; Zjalić Milorad; Prološčić, Ivan; Masud, Mostafa; Blažetić, Senka; Vuković, Ana; Billah, Motasim; Khan, Aslam et al.
AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers // Journal of hazardous materials, 409 (2021), 124918, 11 doi:10.1016/j.jhazmat.2020.124918 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1102121 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers

Autori
Mustapić, Mislav ; Glumac, Zvonko ; Heffer, Marija ; Zjalić Milorad ; Prološčić, Ivan ; Masud, Mostafa ; Blažetić, Senka ; Vuković, Ana ; Billah, Motasim ; Khan, Aslam ; Šegota, Suzana ; Hossain, Md Shahriar

Izvornik
Journal of hazardous materials (0304-3894) 409 (2021); 124918, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Magnetic nanoparticles, Cytotoxicity, Enzyme activity, Oxidative stress

Sažetak
Continuing our previous research work on a drug delivery system based on combined AC/DC magnetic fields, we have developed a prototype AC/DC magnetic syringe device for stimulation of drug release from drug carriers, with the options of injecting/removing drug carriers. The porous Fe3O4 carrier, in a dose-dependent manner, causes acute oxidative damage and reduces the viability of differentiated SH-SY5Y human neuroblastoma cells, indicating the necessity for its removal once it reaches the therapeutic concentration at the target tissue. The working mechanism of the device consists of three simple steps. First, direct injection of the drug adsorbed on the surface of a carrier via a needle inserted into the targeted area. The second step is stimulation of drug release using a combination of AC magnetic field (a coil magnetised needle with AC current) and permanent magnets (DC magnetic lens outside of the body), and the third step is removal of the drug carriers from the injected area after the completion of drug release by magnetising the tip of the needle with DC current. Removing the drug carriers allows us to avoid possible acute and long term side effects of the drug carriers in the patient's body, as well as any potential response of the body to the drug carriers.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
NadSve-Sveučilište J. J. Strossmayera u Osijeku-UNIOS – ZUP 2018-56 - Eksperimentalno i teorijsko modeliranje otpuštanja lijeka sa magnetskih nanočestica u prisustvu vanjskih magnetskih polja (Mustapić, Mislav, NadSve ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Osijek,
Sveučilište u Osijeku - Odjel za biologiju,
Sveučilište u Osijeku - Odjel za fiziku

Citiraj ovu publikaciju

Mustapić, Mislav; Glumac, Zvonko; Heffer, Marija; Zjalić Milorad; Prološčić, Ivan; Masud, Mostafa; Blažetić, Senka; Vuković, Ana; Billah, Motasim; Khan, Aslam et al.
AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers // Journal of hazardous materials, 409 (2021), 124918, 11 doi:10.1016/j.jhazmat.2020.124918 (međunarodna recenzija, članak, znanstveni)
Mustapić, M., Glumac, Z., Heffer, M., Zjalić Milorad, Prološčić, I., Masud, M., Blažetić, S., Vuković, A., Billah, M. & Khan, A. (2021) AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers. Journal of hazardous materials, 409, 124918, 11 doi:10.1016/j.jhazmat.2020.124918.
@article{article, year = {2021}, pages = {11}, DOI = {10.1016/j.jhazmat.2020.124918}, chapter = {124918}, keywords = {Magnetic nanoparticles, Cytotoxicity, Enzyme activity, Oxidative stress}, journal = {Journal of hazardous materials}, doi = {10.1016/j.jhazmat.2020.124918}, volume = {409}, issn = {0304-3894}, title = {AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers}, keyword = {Magnetic nanoparticles, Cytotoxicity, Enzyme activity, Oxidative stress}, chapternumber = {124918} }
@article{article, year = {2021}, pages = {11}, DOI = {10.1016/j.jhazmat.2020.124918}, chapter = {124918}, keywords = {Magnetic nanoparticles, Cytotoxicity, Enzyme activity, Oxidative stress}, journal = {Journal of hazardous materials}, doi = {10.1016/j.jhazmat.2020.124918}, volume = {409}, issn = {0304-3894}, title = {AC/DC magnetic device for safe medical use of potentially harmful magnetic nanocarriers}, keyword = {Magnetic nanoparticles, Cytotoxicity, Enzyme activity, Oxidative stress}, chapternumber = {124918} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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