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Pregled bibliografske jedinice broj: 1101475

Association of proton pump inhibitor use with disease burden and cardiometabolic profile among patients hospitalized for acute myocardial infarction


Bilalić, Admira; Borovac, Josip Anđelo; Tičinović Kurir, Tina; Kumrić, Marko; Matetić, Andrija; Božić, Joško
Association of proton pump inhibitor use with disease burden and cardiometabolic profile among patients hospitalized for acute myocardial infarction // Cardiologia Croatica, 16 (2021), 1-2; 5-5 doi:10.15836/ccar2021.5 (recenziran, kratko priopcenje, znanstveni)


CROSBI ID: 1101475 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of proton pump inhibitor use with disease burden and cardiometabolic profile among patients hospitalized for acute myocardial infarction

Autori
Bilalić, Admira ; Borovac, Josip Anđelo ; Tičinović Kurir, Tina ; Kumrić, Marko ; Matetić, Andrija ; Božić, Joško

Izvornik
Cardiologia Croatica (1848-543X) 16 (2021), 1-2; 5-5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
acute coronary syndrome, acute myocardial infarction, IPP, proton pump inhibitors, outcomes ; comorbidities ; cardiometabolic parameters

Sažetak
Introduction: Previous studies showed an increased likelihood and risk of acute myocardial infarction (AMI) and hospitalizations for cardiovascular events among patients exposed to chronic use of proton pump inhibitors (PPIs).1-3 In this study we aimed to compare parameters reflecting disease burden and cardiometabolic profile among patients treated for AMI with respect to the chronic exposure to PPIs. Patients and Methods: Data of 143 adult consecutive patients hospitalized for ST- elevation myocardial infarction (STEMI) or non- ST-segment elevation myocardial infarction (NSTEMI) during the 2019-2020 period were analyzed. All continuous variables had a normal distribution. Results: The mean age was 64.8 ± 11.3 years and 79.7% were men. Two-thirds (65.7%) of patients had STEMI while 34.3% had NSTEMI. The mean GRACE score in the whole cohort was 117 ± 26 points while 12.6% of patients were at high risk of in-hospital death, after adjustment for the ACS type. A total of 19 IPP+ patients were identified. Patients in the IPP+ group were significantly older and had a higher prevalence of NSTEMI compared to IPP- group while both groups did not significantly differ in terms of sex, body mass index, waist-to-hip ratio, the mean number of diseased vessels at angiography, and left ventricular ejection fraction. Patient IPP+ group had a significantly higher high-sensitivity cardiac troponin I rise from 1st to 2nd measurement compared to IPP- group (4726 ± 5938 vs. 2554 ± 3480 ng/L, p=0.025, Table 1). Furthermore, C- reactive protein, blood glucose, and serum creatinine levels at admission were significantly higher in IPP+ vs. the IPP- group. Finally, patients in the IPP+ group had a significantly higher risk of in-hospital and 6-month post-discharge death compared to IPP- group, as adjudicated by the GRACE score (132 ± 23 vs. 114 ± 26 points, p=0.008). Conclusions: Our study showed that AMI patients with chronic exposure to IPPs are older, mostly male, and tend to present with NSTEMI. These patients exhibit a larger magnitude of myocardial injury and systemic inflammation accompanied by worse renal function, and also seem to be at an increased risk of poor in- hospital and post-discharge outcomes. However, potential confounding of underlying comorbidities and age must be taken into account when interpreting these results.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC Split,
Medicinski fakultet, Split

Citiraj ovu publikaciju

Bilalić, Admira; Borovac, Josip Anđelo; Tičinović Kurir, Tina; Kumrić, Marko; Matetić, Andrija; Božić, Joško
Association of proton pump inhibitor use with disease burden and cardiometabolic profile among patients hospitalized for acute myocardial infarction // Cardiologia Croatica, 16 (2021), 1-2; 5-5 doi:10.15836/ccar2021.5 (recenziran, kratko priopcenje, znanstveni)
Bilalić, A., Borovac, J., Tičinović Kurir, T., Kumrić, M., Matetić, A. & Božić, J. (2021) Association of proton pump inhibitor use with disease burden and cardiometabolic profile among patients hospitalized for acute myocardial infarction. Cardiologia Croatica, 16 (1-2), 5-5 doi:10.15836/ccar2021.5.
@article{article, year = {2021}, pages = {5-5}, DOI = {10.15836/ccar2021.5}, keywords = {acute coronary syndrome, acute myocardial infarction, IPP, proton pump inhibitors, outcomes, comorbidities, cardiometabolic parameters}, journal = {Cardiologia Croatica}, doi = {10.15836/ccar2021.5}, volume = {16}, number = {1-2}, issn = {1848-543X}, title = {Association of proton pump inhibitor use with disease burden and cardiometabolic profile among patients hospitalized for acute myocardial infarction}, keyword = {acute coronary syndrome, acute myocardial infarction, IPP, proton pump inhibitors, outcomes, comorbidities, cardiometabolic parameters} }
@article{article, year = {2021}, pages = {5-5}, DOI = {10.15836/ccar2021.5}, keywords = {acute coronary syndrome, acute myocardial infarction, IPP, proton pump inhibitors, outcomes, comorbidities, cardiometabolic parameters}, journal = {Cardiologia Croatica}, doi = {10.15836/ccar2021.5}, volume = {16}, number = {1-2}, issn = {1848-543X}, title = {Association of proton pump inhibitor use with disease burden and cardiometabolic profile among patients hospitalized for acute myocardial infarction}, keyword = {acute coronary syndrome, acute myocardial infarction, IPP, proton pump inhibitors, outcomes, comorbidities, cardiometabolic parameters} }

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