engleski

Arachidonic acid metabolites and sinonasal polyposis. I. Possible prognostic value

A prospective study was carried out to assess the possible biochemical background of the AAm production by HVF in accordance with selected histological types and voice disorders. The mass of new tissue forming HVF in different clinical cases led us to suspect, according to our previous results, that PGs, LTs and other AAm may be involved in the pathogenesis of HVF. The level of PGE2 in HFV was lower (0.7 ng/ml) than in control (1.09 ng/ml) but not significantly ; the PGI2 level (0.01 ng/ml) in HVF was also nonsignificantly lower than in normals, while thromboxane A2 synthesis by HVF (0.42 ng/ml) was significantly less than in control (0.99 ng/ml). On the basis of these results the hypothesis of a possible role of AAm in the process of HVF could not be confirmed.

arachidonic acid metabolites ; leukotriens ; sinonasal polyposis

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