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Pregled bibliografske jedinice broj: 1100746

KANK family proteins in cancer


Tadijan, Ana; Samaržija, Ivana; Humphries, Jonathan D; Humphries, Martin J.; Ambriović- Ristov, Andreja
KANK family proteins in cancer // International journal of biochemistry & cell biology, 131 (2021), 105903, 5 doi:10.1016/j.biocel.2020.105903 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
KANK family proteins in cancer

Autori
Tadijan, Ana ; Samaržija, Ivana ; Humphries, Jonathan D ; Humphries, Martin J. ; Ambriović- Ristov, Andreja

Izvornik
International journal of biochemistry & cell biology (1357-2725) 131 (2021); 105903, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
KANK ; Focal adhesion ; Cancer ; Cortical microtubule stabilisation complex

Sažetak
The Kank (kidney or KN motif and ankyrin repeat domain-containing) family of proteins has been described as essential for crosstalk between actin and microtubules. Kank1, 2, 3 and 4 arose by gene duplication and diversification and share conserved structural domains. KANK proteins are localised mainly to the plasma membrane in focal adhesions, indirectly affecting RhoA and Rac1 thus regulating actin cytoskeleton. In addition, Kank proteins are part of the cortical microtubule stabilisation complex regulating microtubules. Most of the data have been collected for Kank1 protein whose expression promotes apoptosis and cell- cycle arrest while Kank3 was identified as hypoxia- inducible proapoptotic target of p53. A discrepancy in Kanks role in regulation of cell migration and sensitivity to antitumour drugs has been observed in different cell models. Since expression of Kank1 and 3 correlate positively with tumour progression and patient outcome, at least in some tumour types, they are candidates for tumour suppressors.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-1577 - Integrin alpha V beta 5-povezane fokalne i retikularne adhezije u melanomu (AdMeFoRe) (Ambriović Ristov, Andreja, HRZZ - 2019-04) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Tadijan, Ana; Samaržija, Ivana; Humphries, Jonathan D; Humphries, Martin J.; Ambriović- Ristov, Andreja
KANK family proteins in cancer // International journal of biochemistry & cell biology, 131 (2021), 105903, 5 doi:10.1016/j.biocel.2020.105903 (međunarodna recenzija, pregledni rad, znanstveni)
Tadijan, A., Samaržija, I., Humphries, J., Humphries, M. & Ambriović- Ristov, A. (2021) KANK family proteins in cancer. International journal of biochemistry & cell biology, 131, 105903, 5 doi:10.1016/j.biocel.2020.105903.
@article{article, year = {2021}, pages = {5}, DOI = {10.1016/j.biocel.2020.105903}, chapter = {105903}, keywords = {KANK, Focal adhesion, Cancer, Cortical microtubule stabilisation complex}, journal = {International journal of biochemistry and cell biology}, doi = {10.1016/j.biocel.2020.105903}, volume = {131}, issn = {1357-2725}, title = {KANK family proteins in cancer}, keyword = {KANK, Focal adhesion, Cancer, Cortical microtubule stabilisation complex}, chapternumber = {105903} }
@article{article, year = {2021}, pages = {5}, DOI = {10.1016/j.biocel.2020.105903}, chapter = {105903}, keywords = {KANK, Focal adhesion, Cancer, Cortical microtubule stabilisation complex}, journal = {International journal of biochemistry and cell biology}, doi = {10.1016/j.biocel.2020.105903}, volume = {131}, issn = {1357-2725}, title = {KANK family proteins in cancer}, keyword = {KANK, Focal adhesion, Cancer, Cortical microtubule stabilisation complex}, chapternumber = {105903} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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