Naslov
Recent Advances and Prospects in the Research of Nascent Adhesions

Autori
Stumpf, Bernd Henning ; Ambriović-Ristov, Andreja ; Radenovic, Aleksandra ; Smith, Ana-Sunčana

Izvornik
Frontiers in physiology (1664-042X) 11 (2020); 574371, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
nascent adhesions ; focal adhesions ; integrin activation ; integrin clustering ; superresolution microscopy ; modeling

Sažetak
Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and activation of proteins to build mature focal adhesions. They are also associated with early stage signaling and the mechanoresponse. Despite their crucial role in sampling the local extracellular matrix, very little is known about the mechanism of their formation. Consequently, there is a strong scientific activity focused on elucidating the physical and biochemical foundation of their development and function. Precisely the results of this effort will be summarized in this article.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija

POVEZANOST RADA