engleski

Hyperferritinemia and COVID-19?

It has been repeatedly described that increased serum ferritin concentration or hyperferritinemia is as- sociated with COVID- 19, especially with more severe forms of this disease. Ferritin is a molecule whose concentration is determined as a marker of reflecting the body’s iron supply and less significantly as a marker of inflammation of infectious and non- infectious origin. The expression of this vital molecule for iron metabolism is therefore regulated, primarily by an iron- dependent mechanism. However, in addition to this regulation, there appears to be feedback between ferritin and cytokines in the control of pro-inflammatory and anti-inflammatory mediators. This review paper includes basic data on ferritin and the potential causes and consequences of hyper- ferritinemia with implications for COVID-19.

hyperferritinemia ; COVID-19 ; inflammation ; iron metabolism ; ferritin

nije evidentirano