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Pregled bibliografske jedinice broj: 1100499

Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males


Podobnik, Josip; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Dodig Ćurković, Katarina; Ćurkovic, Mario; Kovač, Vlatka; Švob Štrac, Dubravka; Čusek, Melita; Bortolato, Marco; Pivac, Nela
Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males // Biomolecules, 10 (2020), 11; 1555, 13 doi:10.3390/biom10111555 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1100499 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males

Autori
Podobnik, Josip ; Nikolac Perković, Matea ; Nedić Erjavec, Gordana ; Dodig Ćurković, Katarina ; Ćurkovic, Mario ; Kovač, Vlatka ; Švob Štrac, Dubravka ; Čusek, Melita ; Bortolato, Marco ; Pivac, Nela

Izvornik
Biomolecules (2218-273X) 10 (2020), 11; 1555, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
juvenile correctional facility ; delinquent behavior ; platelet MAO-B activity ; MAOB rs1799836 polymorphism ; conduct disorder

Sažetak
Juvenile delinquency is related to several biological factors, yet very few vulnerability biomarkers have been identified. Previous data suggest that the enzyme monoamine oxidase B (MAO-B) influences several personality traits linked to the propensity to engage in delinquent behavior. Building on this evidence, we assessed whether conduct disorder (CD), juvenile delinquency adjudications, or detention in a correctional facility were associated with either platelet MAO-B activity or the MAOB rs1799836 polymorphism. The study enrolled 289 medication-free male youths, including 182 individuals detained in a correctional facility (with or without a diagnosis of CD). Of the remaining 107 participants, 26 subjects had a diagnosis of CD, and 81 were mentally healthy controls. Platelet MAO-B activity was determined by spectrophotofluorometry, while MAOB rs1799836 was genotyped using qPCR. Platelet MAO-B activity, corrected for age and smoking, was significantly higher in juvenile detainees (p < 0.001), irrespective of CD diagnosis. MAOB rs1799836 was not associated with platelet MAO-B activity or with detention in a correctional facility, CD diagnosis, or delinquent behavior. These data suggest that detention in a juvenile correctional facility increases platelet MAO-B activity in male adolescents. Future studies are needed to determine the mechanisms and functional significance of MAO-B peripheral elevation in juvenile male detainees

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Psihologija



POVEZANOST RADA


Projekti:
MZOS-098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Osijek,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Podobnik, Josip; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Dodig Ćurković, Katarina; Ćurkovic, Mario; Kovač, Vlatka; Švob Štrac, Dubravka; Čusek, Melita; Bortolato, Marco; Pivac, Nela
Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males // Biomolecules, 10 (2020), 11; 1555, 13 doi:10.3390/biom10111555 (međunarodna recenzija, članak, znanstveni)
Podobnik, J., Nikolac Perković, M., Nedić Erjavec, G., Dodig Ćurković, K., Ćurkovic, M., Kovač, V., Švob Štrac, D., Čusek, M., Bortolato, M. & Pivac, N. (2020) Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males. Biomolecules, 10 (11), 1555, 13 doi:10.3390/biom10111555.
@article{article, year = {2020}, pages = {13}, DOI = {10.3390/biom10111555}, chapter = {1555}, keywords = {juvenile correctional facility, delinquent behavior, platelet MAO-B activity, MAOB rs1799836 polymorphism, conduct disorder}, journal = {Biomolecules}, doi = {10.3390/biom10111555}, volume = {10}, number = {11}, issn = {2218-273X}, title = {Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males}, keyword = {juvenile correctional facility, delinquent behavior, platelet MAO-B activity, MAOB rs1799836 polymorphism, conduct disorder}, chapternumber = {1555} }
@article{article, year = {2020}, pages = {13}, DOI = {10.3390/biom10111555}, chapter = {1555}, keywords = {juvenile correctional facility, delinquent behavior, platelet MAO-B activity, MAOB rs1799836 polymorphism, conduct disorder}, journal = {Biomolecules}, doi = {10.3390/biom10111555}, volume = {10}, number = {11}, issn = {2218-273X}, title = {Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males}, keyword = {juvenile correctional facility, delinquent behavior, platelet MAO-B activity, MAOB rs1799836 polymorphism, conduct disorder}, chapternumber = {1555} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus
  • MEDLINE


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