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Isolated nodular amyloidosis of the breast associated with monoclonal gamapathy (IgG) – Case report

Amyloidosis is an abnormal deposition of insoluble amyloid proteins in extracellular spaces. Protein deposits are components of immunoglobulins produced by plasma cells and B–lymphocytes in response to antigenic stimulation. Three different forms of systemic amyloidosis can be distinguished, those are primary (AL), secondary (AA) and family form. Localized amyloidosis occurs in the pancreas in type 2 diabetic patients and in patients on chronic hemodialysis. Amyloidosis of the breast is a rare entity, mostly involving elderly women, and may be misdiagnosed as carcinoma on mammography. A 70 years old woman presented with monoclonal IgG gamapathy, hydronephrosis, acute renal insufficiency and suspicious lesion in the breast on ultrasound. Mammography revealed a lobulated, ill demarcated area without visible microcalcifications.

amyloidosis, breast, monoclonal IgG gamapathy

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