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Pregled bibliografske jedinice broj: 1099607

Comparative analysis of OCT ¾  and c-KIT in the testicular seminoma


Raos, Dora; Mašić, Silvija; Katušić Bojanac, Ana; Tomić, Miroslav; Bulić-Jakuš, Floriana; Ježek, Davor; Tomašković, Igor; Sinčić, Nino; Ulamec, Monika
Comparative analysis of OCT ¾  and c-KIT in the testicular seminoma // Book of Abstracts: 3rd Andrology Syposium
Zagreb, Croatia, 2019. str. 61-62 (poster, domaća recenzija, sažetak, znanstveni)


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Naslov
Comparative analysis of OCT ¾  and c-KIT in the testicular seminoma

Autori
Raos, Dora ; Mašić, Silvija ; Katušić Bojanac, Ana ; Tomić, Miroslav ; Bulić-Jakuš, Floriana ; Ježek, Davor ; Tomašković, Igor ; Sinčić, Nino ; Ulamec, Monika

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts: 3rd Andrology Syposium / - , 2019, 61-62

Skup
3rd Andrology Symposium

Mjesto i datum
Zagreb, Croatia, 6.6.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Seminoma ; Oct 3/4 ; C-kit
(seminoma ; oct 3/4 ; C-kit)

Sažetak
Testicular seminoma belongs to testicular germ cell tumours (TGCT) which represent 95% of all testicular neoplasia. TGCT represent well recognized challenge in the frame of male reproductive health because TGTC affect young male population. TGCT are classified into seminoma and non-seminoma based on their degree of differentiation and histological characteristic. In routine diagnosis of TGCT, OCT ¾ and c-KIT are used as a biomarker for seminoma and embryonal carcinoma. The aim of this study, was to compare the expression of c- KIT gene with the expression of OCT ¾ in seminoma tissue. In this study, 52 seminoma tissue were collected. All seminoma tissue were embedded in paraffin and cut to 5 µm slides which were immunohistochemically stained. We used specific antibodies for visualization of OCT ¾ and c-KIT. Morphometric analysis for OCT ¾ and c-KIT expression was performed by pathologist. c-KIT and OCT ¾ were expressed in all seminoma tissue. Furthermore, out of 48 tissue samples, in more than 50% of seminoma cells c-KIT was present in 38 patients while OCT ¾ in just 23 samples analysed. There is a study in which we want to investigate different diagnostic, prognostic and possibly biomarkers for testicular seminoma and this research is a part of this bigger study. Give to our results, after the comparison of the expression of this biomarkers which are already being used in the routine diagnosis for testicular seminoma, c- KIT has a higher specificity then OCT ¾.

Izvorni jezik
Engleski



POVEZANOST RADA



Citiraj ovu publikaciju

Raos, Dora; Mašić, Silvija; Katušić Bojanac, Ana; Tomić, Miroslav; Bulić-Jakuš, Floriana; Ježek, Davor; Tomašković, Igor; Sinčić, Nino; Ulamec, Monika
Comparative analysis of OCT ¾  and c-KIT in the testicular seminoma // Book of Abstracts: 3rd Andrology Syposium
Zagreb, Croatia, 2019. str. 61-62 (poster, domaća recenzija, sažetak, znanstveni)
Raos, D., Mašić, S., Katušić Bojanac, A., Tomić, M., Bulić-Jakuš, F., Ježek, D., Tomašković, I., Sinčić, N. & Ulamec, M. (2019) Comparative analysis of OCT ¾  and c-KIT in the testicular seminoma. U: Book of Abstracts: 3rd Andrology Syposium.
@article{article, year = {2019}, pages = {61-62}, keywords = {Seminoma, Oct 3/4, C-kit}, title = {Comparative analysis of OCT ¾  and c-KIT in the testicular seminoma}, keyword = {Seminoma, Oct 3/4, C-kit}, publisherplace = {Zagreb, Croatia} }
@article{article, year = {2019}, pages = {61-62}, keywords = {seminoma, oct 3/4, C-kit}, title = {Comparative analysis of OCT ¾  and c-KIT in the testicular seminoma}, keyword = {seminoma, oct 3/4, C-kit}, publisherplace = {Zagreb, Croatia} }




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