Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1099338

Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach


Pisk, Jana; Đilović, Ivica; Hrenar, Tomica; Cvijanović, Danijela; Pavlović, Gordana; Vrdoljak, Višnja
Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach // RSC Advance, 10 (2020), 38566-38577 doi:10.1039/D0RA06845D (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1099338 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach

Autori
Pisk, Jana ; Đilović, Ivica ; Hrenar, Tomica ; Cvijanović, Danijela ; Pavlović, Gordana ; Vrdoljak, Višnja

Izvornik
RSC Advance (2046-2069) 10 (2020); 38566-38577

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hydrazones ; quinazolines ; Schiff bases

Sažetak
Synthesis of hydrazones (1a–4a and 1b–4b), quinazolines (3c*MeOH and 3d*MeOH), and hydrazone- Schiff bases (4c and 4d) is achieved by combining suitable aldehydes (2, 3- or 2, 4- ihydroxybenzaldehyde) with four hydrazides (isonicotinic, nicotinic, and 2- or 4-aminobenzoic acid hydrazide). A suite of approaches for their preparation is described: solution-based synthesis, mechanosynthesis, and solid-state melt reactions. The mechanochemical approach is generally a better choice for the quinazolines, while the solid-state melt reaction is more efficient for derivatives of (iso)nicotinic based hydrazones. Crystalline amine-functionalised hydrazones 4a and 4b undergo post-synthetic modifications in reactions with 3- or 4-pyridinecarbaldehyde vapours to form hydrazone-Schiff bases 4a-3py, 4b-3py, 4a-4py, and 4b4py. Mechanochemical and vapour-mediated reactions are followed by ex situ powder X-ray diffraction and IR-ATR methods, respectively. The chemometric analysis of these data using principal component analysis provided an insight into the reaction profiles and reaction times. Azines (5a and 5b), achieved from aldehydes and hydrazine, reversibly change colour in response to temperature changes. The structures of all products are ascertained by a combined use of spectroscopic and X-ray diffraction methods. The cytotoxic and antimicrobial activities of all compounds against selected human cancer cell lines and bacterial strains are evaluated.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-4221 - Metalosupramolekulske strukture i anorgansko-organski polioksometalatni hibridi (MOLART) (Vrdoljak, Višnja, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Tekstilno-tehnološki fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi pubs.rsc.org

Citiraj ovu publikaciju:

Pisk, Jana; Đilović, Ivica; Hrenar, Tomica; Cvijanović, Danijela; Pavlović, Gordana; Vrdoljak, Višnja
Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach // RSC Advance, 10 (2020), 38566-38577 doi:10.1039/D0RA06845D (međunarodna recenzija, članak, znanstveni)
Pisk, J., Đilović, I., Hrenar, T., Cvijanović, D., Pavlović, G. & Vrdoljak, V. (2020) Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach. RSC Advance, 10, 38566-38577 doi:10.1039/D0RA06845D.
@article{article, author = {Pisk, Jana and \DJilovi\'{c}, Ivica and Hrenar, Tomica and Cvijanovi\'{c}, Danijela and Pavlovi\'{c}, Gordana and Vrdoljak, Vi\v{s}nja}, year = {2020}, pages = {38566-38577}, DOI = {10.1039/D0RA06845D}, keywords = {hydrazones, quinazolines, Schiff bases}, journal = {RSC Advance}, doi = {10.1039/D0RA06845D}, volume = {10}, issn = {2046-2069}, title = {Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach}, keyword = {hydrazones, quinazolines, Schiff bases} }
@article{article, author = {Pisk, Jana and \DJilovi\'{c}, Ivica and Hrenar, Tomica and Cvijanovi\'{c}, Danijela and Pavlovi\'{c}, Gordana and Vrdoljak, Vi\v{s}nja}, year = {2020}, pages = {38566-38577}, DOI = {10.1039/D0RA06845D}, keywords = {hydrazones, quinazolines, Schiff bases}, journal = {RSC Advance}, doi = {10.1039/D0RA06845D}, volume = {10}, issn = {2046-2069}, title = {Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach}, keyword = {hydrazones, quinazolines, Schiff bases} }

Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font