engleski

Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites

Eight new 7-substituted quinolin-8-ol derivatives were synthesized in moderate to good yields through quinolin-8-ol, and secondary amines as the starting reagents. The struc- tures of the prepared compounds have been characterized by elemental analysis and 1 H/ 13 C NMR. The antimicrobial activity of this new series of heterocyclic compounds has been achieved "in vitro" against some bacterial strains by means of the disk method, and most of the tested compounds have shown comparable or greater antibacterial ac- tivity than nitroxoline (standard antibiotic). It was very motivating to observe that POM (Petra/Osiris/Molinspiration) bioinformatic analyses of compound 5 exhibited better an- tibacterial activity (MIC = 10 μg/mL against B. subtilis bacteria), and higher drug score (DS = 0.57) compared with Nitroxoline (DS = 0.47 ; MIC = 20 μg/mL). Molecular docking investigations were also conducted to investigate the binding affinities as well as interac- tions of some compounds with the target proteins.

synthesis; quinolin-8-ol; docking; POM (Petra/Osiris/Molinspiration analyses) antibacterial pharmacophore site

nije evidentirano