engleski

Bilastine affects the histamine system in rat male offspring

Introduction. Although drug therapies ought to be avoided during pregnancy, at times in practice, especially in cases of pregnant women suffering from allergies, they are unavoidable and histamine antagonists are applied. They should be applied with caution because of the presence of a transient histamine-containing neuronal network during development of the central nervous system so that the proper neuronal development is not interrupted during the treatment of the mother. The aim of this study was to observe the behavioral phenotype of the offspring from mothers treated with histamine antagonists during pregnancy. Material and methods. Three animal groups each comprised of 6 male and 6 female Sprague-Dawley rats aged 3 months were submitted to the following behavioral tests: activity cage (to measure spontaneous coordinated activity in rats) and open field test (to assay general locomotor activity levels, anxiety, and exploratory behavior). Rats were the offspring of females treated with the antihistamines bilastine or desloratadine from gestation day 10 until delivery (experimental groups) and offspring of untreated females (control group). Results. In comparison to the control group significant differences were observed in body mass, locomotor activity and exploratory behavior of the male offspring from mothers treated with bilastine. Discussion and conclusions. The same animals were observed at the age of 1 month. Although no differences between experimental and control groups were observed at that age, some differences emerged when they reached the age of 3 months. Males from the mothers treated with bilastine had lower body mass and activity suggesting bilastine affected their histamine system.

Histamine antagonists ; Sprague-Dawley rats ; behavior tests ; brain

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