Redoks-svojstva ferocenom supstituiranih nukleobaza (CROSBI ID 287108)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Toma, Mateja ; Vrček, Valerije
hrvatski
Redoks-svojstva ferocenom supstituiranih nukleobaza
A series of ferrocene-substituted purine- nucleobase derivatives 1-10 were synthesized and their redox potential was measured by cyclic voltammetry. Measured compounds showed a reversible one-electron oxidation in the range of 330–470 mV. A difference of 100 mV between N7 and N9 regioisomers was observed. In order to examine the tendency of ferrocene-nucleobase conjugates to produce reactive oxygen species (ROS), an acellular screening with DCFH2-DA assay was carried out. The nucleobases coupled with ferrocene generated ROS, while neither ferrocene itself nor the nucleobases were active. Changing the substituents on the purine ring can significantly influence the ROS generation of ferrocene-substituted nucleobases, which support design of biologically active ferrocene-nucleobase conjugates.
ferocenski konjugati nukleobaza ; redoks-potencijal ; reaktivne kisikove vrste ; ROS
XIII. susret mladih kemijskih inženjera, Zagreb, 20- -21. veljače 2020.
engleski
Redox properties of ferrocene-substituted nucleobases
nije evidentirano
ferrocene-substituted purine-nucleobase ; redox potential ; reactive oxygen species ; ROS
nije evidentirano
Podaci o izdanju
69 (13)
2020.
P21-P29
objavljeno
0022-9830
1334-9090
10.15255/KUI.2020.025
Povezanost rada
Farmacija, Kemija, Kemijsko inženjerstvo