Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

The Role of HLA and KIR Immunogenetics in BK Virus Infection after Kidney Transplantation (CROSBI ID 286940)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Burek Kamenarić, Marija ; Ivković, Vanja ; Kovačević Vojtušek, Ivana ; Žunec, Renata The Role of HLA and KIR Immunogenetics in BK Virus Infection after Kidney Transplantation // Viruses, 12 (2020), 12; 984569, 21. doi: 10.3390/v12121417

Podaci o odgovornosti

Burek Kamenarić, Marija ; Ivković, Vanja ; Kovačević Vojtušek, Ivana ; Žunec, Renata

engleski

The Role of HLA and KIR Immunogenetics in BK Virus Infection after Kidney Transplantation

BK virus (BKV) is a polyomavirus with high seroprevalence in the general population with an unremarkable clinical presentation in healthy people, but a potential for causing serious complications in immunosuppressed transplanted patients. Reactivation or primary infection in kidney allograft recipients may lead to allograft dysfunction and subsequent loss. Currently, there is no widely accepted specific treatment for BKV infection and reduction of immunosuppressive therapy is the mainstay therapy. Given this and the sequential appearance of viruria-viremia-nephropathy, screening and early detection are of utmost importance. There are numerous risk factors associated with BKV infection including genetic factors, among them human leukocyte antigens (HLA) and killer cell immunoglobulin-like receptors (KIR) alleles have been shown to be the strongest so far. Identification of patients at risk for BKV infection would be useful in prevention or early action to reduce morbidity and progression to frank nephropathy. Assessment of risk involving HLA ligands and KIR genotyping of recipients in the pre-transplant or early post-transplant period might be useful in clinical practice. This review summarizes current knowledge of the association between HLA, KIR and BKV infection and potential future directions of research, which might lead to optimal utilization of these genetic markers.

BK virus ; BK virus-associated nephropathy ; kidney transplantation ; human leukocyte antigen ; killer-cell immunoglobulin-like receptor ; natural killer cells

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

12 (12)

2020.

984569

21

objavljeno

1999-4915

10.3390/v12121417

Povezanost rada

nije evidentirano

Poveznice
Indeksiranost